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p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells.Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults.Report from the second cytomegalovirus and immunosenescence workshop.Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RACytomegalovirus infection reduces telomere length of the circulating T cell pool.KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells.Differing HLA types influence inhibitory receptor signalling in CMV-specific CD8+ T cells.
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Stephen J Griffiths
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Stephen James Griffiths
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Stephen James Griffiths
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Stephen James Griffiths
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Stephen James Griffiths
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0000-0003-1701-9632