Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077).
about
Hippocalcin: a new solution to an old puzzle.Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channelsExtracellular sodium modulates the excitability of cultured hippocampal pyramidal cellsSmall-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neuronsKisspeptin inhibits a slow afterhyperpolarization current via protein kinase C and reduces spike frequency adaptation in GnRH neurons.Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late AfterhyperpolarizationIntrinsic properties and neuropharmacology of midline paraventricular thalamic nucleus neurons.Neuromodulatory signaling in hippocampus-dependent memory retrieval.Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex.Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons.The calcium-activated slow AHP: cutting through the Gordian knot.Ca2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors.Calcium influx through N-type channels and activation of SK and TRP-like channels regulates tonic firing of neurons in rat paraventricular thalamus.Properties of a T-type Ca2+channel-activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons.SK (KCa2) channels do not control somatic excitability in CA1 pyramidal neurons but can be activated by dendritic excitatory synapses and regulate their impact.Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex.Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation.Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model.Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.9-Phenanthrol modulates postinhibitory rebound and afterhyperpolarizing potentials in an excitatory motor neuron of the medicinal leech.Prefrontal Neuronal Excitability Maintains Cocaine-Associated Memory During Retrieval.
P2860
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P2860
Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077).
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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name
Enhancement of hippocampal pyr ...... olarization channel blocker 3-
@nl
Enhancement of hippocampal pyr ...... minomethyl)pyridine (UCL2077).
@en
type
label
Enhancement of hippocampal pyr ...... olarization channel blocker 3-
@nl
Enhancement of hippocampal pyr ...... minomethyl)pyridine (UCL2077).
@en
prefLabel
Enhancement of hippocampal pyr ...... olarization channel blocker 3-
@nl
Enhancement of hippocampal pyr ...... minomethyl)pyridine (UCL2077).
@en
P2093
P2860
P356
P1476
Enhancement of hippocampal pyr ...... minomethyl)pyridine (UCL2077).
@en
P2093
C Robin Ganellin
David C H Benton
Dennis G Haylett
Mala M Shah
Mazyar Javadzadeh-Tabatabaie
P2860
P304
P356
10.1124/MOL.106.026625
P577
2006-07-28T00:00:00Z