D-amino acid oxidase activity and expression are increased in schizophrenia. - Wikidata - wikimedia - TriplyDB

D-amino acid oxidase activity and expression are increased in schizophrenia.

D-amino acid oxidase activity and expression are increased in schizophrenia.

http://www.wikidata.org/entity/Q43195422

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Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum The association of schizophrenia risk D-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy males.Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.Clinical and biochemical study of d-serine metabolism among schizophrenia patients.The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients Activity of D-amino acid oxidase is widespread in the human central nervous system.A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains Adaptive evolution and elucidating the potential inhibitor against schizophrenia to target DAOA (G72) isoforms.Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits.Pharmacoinformatics, Adaptive Evolution, and Elucidation of Six Novel Compounds for Schizophrenia Treatment by Targeting DAOA (G72) Isoforms.Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption.Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP)The C-terminal region of G72 increases D-amino acid oxidase activity.D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).Identification of two promoters for human D-amino acid oxidase gene: implication for the differential promoter regulation mediated by PAX5/PAX2.Enzymatic transamination of D-kynurenine generates kynurenic acid in rat and human brain.Role of D-amino acid oxidase in the production of kynurenine pathway metabolites from D-tryptophan in mice.The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.A method for the determination of D-kynurenine in biological tissues.Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View.Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma.Validation of tautomeric and protomeric binding modes by free energy calculations. A case study for the structure based optimization of D-amino acid oxidase inhibitors.A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia.Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo.Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer.Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.Elucidation of inhibitor-binding pockets of d-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology.Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies.

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D-amino acid oxidase activity and expression are increased in schizophrenia.

http://www.wikidata.org/entity/Q43195422

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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name

D-amino acid oxidase activity and expression are increased in schizophrenia.

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D-amino acid oxidase activity and expression are increased in schizophrenia.

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type

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D-amino acid oxidase activity and expression are increased in schizophrenia.

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D-amino acid oxidase activity and expression are increased in schizophrenia.

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D-amino acid oxidase activity and expression are increased in schizophrenia.

@en

D-amino acid oxidase activity and expression are increased in schizophrenia.

@nl

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Molecular Psychiatry

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D-amino acid oxidase activity and expression are increased in schizophrenia

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B R Godlewska

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M Walker

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P J Harrison

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S L Eastwood

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P2860

d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1).

A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia.

Glutamatergic mechanisms in schizophrenia.

Glycine transport inhibitors and the treatment of schizophrenia.

In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties.

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658-660

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10.1038/MP.2008.47

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Pilleriin Sikka

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