Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle. - Wikidata - wikimedia - TriplyDB

Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle.

Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle.

http://www.wikidata.org/entity/Q43195715

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Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly Assembly-Directed Antivirals Differentially Bind Quasiequivalent Pockets to Modify Hepatitis B Virus Capsid Tertiary and Quaternary Structure DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus All-Atom Molecular Dynamics of Virus Capsids as Drug Targets The thermodynamics of virus capsid assembly.Allosteric conformational changes of human HBV core protein transform its assembly.Exploring the paths of (virus) assembly Trapping of hepatitis B virus capsid assembly intermediates by phenylpropenamide assembly accelerators.HBV life cycle: entry and morphogenesis.Evolution and protein packaging of small-molecule RNA aptamers.A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formation Carbonyl J acid derivatives block protein priming of hepadnaviral P protein and DNA-dependent DNA synthesis activity of hepadnaviral nucleocapsids.Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation.High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein Phase diagrams map the properties of antiviral agents directed against hepatitis B virus core assembly Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket Virus assembly, allostery and antivirals HBV life cycle and novel drug targets.Recent advance of the hepatitis B virus inhibitors: a medicinal chemistry overview.Core protein: A pleiotropic keystone in the HBV lifecycle.Assembly and Release of Hepatitis B Virus.Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus.Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture.HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly.Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms Protein-Protein Interfaces in Viral Capsids Are Structurally Unique.Charge Detection Mass Spectrometry Identifies Preferred Non-Icosahedral Polymorphs in the Self-Assembly of Woodchuck Hepatitis Virus Capsids.A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly Structurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly.The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription.HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways.The Structural Biology of Hepatitis B Virus: Form and Function.A minimal representation of the self-assembly of virus capsids.Hepatitis virus capsid polymorph stability depends on encapsulated cargo size.Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids.Hepatitis B core protein as a therapeutic target.Global strategies are required to cure and eliminate HBV infection.

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P2860

Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle.

http://www.wikidata.org/entity/Q43195715

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2008 nî lūn-bûn

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Angela Lee

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Bollu Venkataiah

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Brent Korba

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Christina Bourne

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Sejin Lee

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P2860

The crystal structure of the human hepatitis B virus capsid

Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy

Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating.

Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.

A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly

Hepatitis B virus biology.

Virus Particle Explorer (VIPER), a website for virus capsid structures and their computational analyses.

Kinetic analysis of the effect of poliovirus receptor on viral uncoating: the receptor as a catalyst.

Development of resistance and perspectives for future therapies against hepatitis B infections: lessons to be learned from HIV.

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10262-10270

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