Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors.
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The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathwayThe toxicity of amyloid β oligomersAmyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresOrganotypic Cultures as a Model to Study Adult Neurogenesis in CNS DisordersOrganotypic brain slice cultures: A reviewAlzheimer's disease and insulin resistance: translating basic science into clinical applicationsAmyloid beta: multiple mechanisms of toxicity and only some protective effects?Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.Molecular mechanisms of cognitive dysfunction following traumatic brain injuryFrom single target to multitarget/network therapeutics in Alzheimer's therapyProtection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols.Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal NeuronsComputational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityCSF and Brain Indices of Insulin Resistance, Oxidative Stress and Neuro-Inflammation in Early versus Late Alzheimer's DiseaseEffect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance.Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies.Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate.Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction.The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathologyHypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia.Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology.Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities.Induction of neuronal activation by femtosecond-pulsed laser irradiation and its potential application for amyloid-β-induced toxicity assessment.Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neuronsForebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures.Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD.NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseaseGlutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathologyInteractions between oestrogen and the renin angiotensin system - potential mechanisms for gender differences in Alzheimer's disease.1-42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death.A genetically immortalized human stem cell line: a promising new tool for Alzheimer's disease therapy.Parishin C's prevention of Aβ 1-42-induced inhibition of long-term potentiation is related to NMDA receptorsMediation of Autophagic Cell Death by Type 3 Ryanodine Receptor (RyR3) in Adult Hippocampal Neural Stem CellsCurcumin: a natural substance with potential efficacy in Alzheimer's disease.
P2860
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P2860
Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Amyloid beta oligomers induce ...... onotropic glutamate receptors.
@en
Amyloid beta oligomers induce ...... onotropic glutamate receptors.
@nl
type
label
Amyloid beta oligomers induce ...... onotropic glutamate receptors.
@en
Amyloid beta oligomers induce ...... onotropic glutamate receptors.
@nl
prefLabel
Amyloid beta oligomers induce ...... onotropic glutamate receptors.
@en
Amyloid beta oligomers induce ...... onotropic glutamate receptors.
@nl
P50
P1433
P1476
Amyloid beta oligomers induce ...... ionotropic glutamate receptors
@en
P2093
Fabio Cavaliere
José Luis Zugaza
P304
P356
10.1016/J.CECA.2009.12.010
P50
P577
2010-01-12T00:00:00Z