Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
about
Ubiquitin modificationsUbiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentParkin Regulation and Neurodegenerative DisordersExpanding the ubiquitin code through post-translational modificationThe critical roles of mitophagy in cerebral ischemiaMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Probes of ubiquitin E3 ligases enable systematic dissection of parkin activationStructural insights into Parkin substrate lysine targeting from minimal Miro substratesStructure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationStructure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkinStructure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.Specificity and disease in the ubiquitin systemParkin Regulates the Activity of Pyruvate Kinase M2Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.The mitochondrial kinase PINK1: functions beyond mitophagy.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Parkin and PINK1 functions in oxidative stress and neurodegeneration.Post translational modification of Parkin.Ubiquitin and Parkinson's disease through the looking glass of genetics.Twenty years since the discovery of the parkin gene.pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit.The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.Determination of the pKa of the N-terminal amino group of ubiquitin by NMR.Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.Dual Function of Phosphoubiquitin in E3 Activation of Parkin.Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.Molecular dynamics simulations of human E3 ubiquitin ligase Parkin.Structure of PINK1 in complex with its substrate ubiquitin.Mammalian mitophagy - from in vitro molecules to in vivo models.An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.Mechanism and regulation of the Lys6-selective deubiquitinase USP30.Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.RING-Between-RING E3 Ligases: Emerging Themes amid the Variations.
P2860
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P2860
Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh-hant
name
Disruption of the autoinhibite ...... for activation and catalysis.
@en
Disruption of the autoinhibite ...... for activation and catalysis.
@nl
type
label
Disruption of the autoinhibite ...... for activation and catalysis.
@en
Disruption of the autoinhibite ...... for activation and catalysis.
@nl
prefLabel
Disruption of the autoinhibite ...... for activation and catalysis.
@en
Disruption of the autoinhibite ...... for activation and catalysis.
@nl
P2093
P2860
P50
P356
P1433
P1476
Disruption of the autoinhibite ...... n for activation and catalysis
@en
P2093
Axel Knebel
Helen Walden
Kathryn R Barber
Pascal Mercier
Rachel Toth
Ramasubramanian Sundaramoorthy
Tara E C Condos
P2860
P304
P356
10.15252/EMBJ.201592337
P407
P577
2015-08-07T00:00:00Z