Metabolism and excretion of the novel bioreductive prodrug PR-104 in mice, rats, dogs, and humans.

Metabolism and excretion of the novel bioreductive prodrug PR-104 in mice, rats, dogs, and humans.

Item
http://www.wikidata.org/entity/Q43216703
Prodrugs of phosphonates and phosphates: crossing the membrane barrierSulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104AA phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients.PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumoursInitial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104.Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling.Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice.Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.
P2860

Metabolism and excretion of the novel bioreductive prodrug PR-104 in mice, rats, dogs, and humans.

Item
http://www.wikidata.org/entity/Q43216703
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年學術文章
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2009年學術文章
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Metabolism and excretion of th ...... mice, rats, dogs, and humans.
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Metabolism and excretion of th ...... mice, rats, dogs, and humans.
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Metabolism and excretion of th ...... mice, rats, dogs, and humans.
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Metabolism and excretion of th ...... mice, rats, dogs, and humans.
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Metabolism and excretion of th ...... mice, rats, dogs, and humans.
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Metabolism and excretion of th ...... mice, rats, dogs, and humans.
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Metabolism and excretion of th ...... mice, rats, dogs, and humans.
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P356
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P478
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P5875
P698