Modulation of Hsf1 activity by novobiocin and geldanamycin.
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Hold me tight: Role of the heat shock protein family of chaperones in cardiac diseaseClient Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted MutantsMolecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent mannerGambogic acid, a natural product inhibitor of Hsp90Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Lung cancer therapeutics that target signaling pathways: an update.Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cellsHsp90 molecular chaperone inhibitors: are we there yet?Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice.Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors.Implication of heat shock factors in tumorigenesis: therapeutical potential.Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors.Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors.Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.Targeting Hsp90 and its co-chaperones to treat Alzheimer's diseaseTargeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.Targeting HSF1 sensitizes cancer cells to HSP90 inhibition.Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.Development of a Grp94 inhibitor.Identification of a new scaffold for hsp90 C-terminal inhibitionA thiol probe for measuring unfolded protein load and proteostasis in cells.Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs.A biosensor-based framework to measure latent proteostasis capacity.Synthesis and Biological Evaluation of Stilbene Analogues as Hsp90 C-Terminal Inhibitors.Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells.Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer
P2860
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P2860
Modulation of Hsf1 activity by novobiocin and geldanamycin.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Modulation of Hsf1 activity by novobiocin and geldanamycin.
@en
Modulation of Hsf1 activity by novobiocin and geldanamycin.
@nl
type
label
Modulation of Hsf1 activity by novobiocin and geldanamycin.
@en
Modulation of Hsf1 activity by novobiocin and geldanamycin.
@nl
prefLabel
Modulation of Hsf1 activity by novobiocin and geldanamycin.
@en
Modulation of Hsf1 activity by novobiocin and geldanamycin.
@nl
P2093
P2860
P356
P1476
Modulation of Hsf1 activity by novobiocin and geldanamycin
@en
P2093
Manoj Nair
Nick Ovsenek
Ruth F O'Carroll
Zachery R Belak
P2860
P304
P356
10.1139/O09-049
P50
P577
2009-12-01T00:00:00Z