about
Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodiesProduction of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line systemThe Structure of a Chondroitin Sulfate-binding Domain Important in Placental MalariaTic22 Is an Essential Chaperone Required for Protein Import into the ApicoplastEngineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal AntibodiesStructure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.Evolution of the primate trypanolytic factor APOL1Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies.A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies.Severe malaria is associated with parasite binding to endothelial protein C receptorStructural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.The structural basis for CD36 binding by the malaria parasite.Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptorThree's company: component structures bring a closer view of tripartite drug efflux pumps.Mapping the Binding Site of a Cross-Reactive Plasmodium falciparum PfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding.A Receptor's Tale: An Eon in the Life of a Trypanosome ReceptorChondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes.One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen.Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains.Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.Carbohydrate binding molecules in malaria pathology.Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein familiesAccelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal 'C-tag'.On the state of crystallography at the dawn of the electron microscopy revolution.Molecular architecture of a retinal cGMP-gated channel: the arrangement of the cytoplasmic domains.Fragments of bacterial endoglycosidase s and immunoglobulin g reveal subdomains of each that contribute to deglycosylation.Calnexin co-expression and the use of weaker promoters increase the expression of correctly assembled Shaker potassium channel in insect cells.Oligomerization and activation of the FliI ATPase central to bacterial flagellum assembly.Overproduction, purification and crystallization of PfTic22, a component of the import apparatus from the apicoplast of Plasmodium falciparum.The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognitionConformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1.The structure of serum resistance-associated protein and its implications for human African trypanosomiasis.In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum.A new site of attack for a malaria vaccine.Production, quality control, stability, and potency of cGMP-produced RH5.1 protein vaccine expressed in S2 cells
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description
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հետազոտող
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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Matthew K. Higgins
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P106
P1153
7202136396
P21
P31
P496
0000-0002-2870-1955