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Studies of the molecular mechanism of caspase-8 activation by solution NMR.

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

http://www.wikidata.org/entity/Q43256262

about

DED or alive: assembly and regulation of the death effector domain complexes Caspase-8 as a regulator of tumor cell motility In silicoidentification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.Role of caspase-8 in thymus function.Caspase-8 as a therapeutic target in cancer.Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate.Src-inducible association of CrkL with procaspase-8 promotes cell migration.Metacaspases versus caspases in development and cell fate regulation.Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis.Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.Caspase activation via Death Receptors in the presence of ligand Dimerization of procaspase-8

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P2860

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

http://www.wikidata.org/entity/Q43256262

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh-hant

name

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

@en

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

@nl

type

label

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

@en

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

@nl

prefLabel

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

@en

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

@nl

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Cell Death & Differentiation

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Studies of the molecular mechanism of caspase-8 activation by solution NMR.

@en

P2093

M G Grütter

http://www.w3.org/2001/XMLSchema#string

N Keller

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O Zerbe

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P2860

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex

Dimer formation drives the activation of the cell death protease caspase 9

Conformational restrictions in the active site of unliganded human caspase-3

Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation

Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation

L2′ loop is critical for caspase-7 active site formation

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710-718

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10.1038/CDD.2009.155

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4

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17

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1049994327

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