Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation
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DED or alive: assembly and regulation of the death effector domain complexesCaspase-8 as a regulator of tumor cell motilityIn silicoidentification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moietyPorphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine PeptidasesProcaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomainIntra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.Modifying caspase-3 activity by altering allosteric networks.Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interfaceSmall Molecule Active Site Directed Tools for Studying Human CaspasesTyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-SrcProteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9Role of caspase-8 in thymus function.Caspase-8 as a therapeutic target in cancer.Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate.Redesigning the procaspase-8 dimer interface for improved dimerization.Src-inducible association of CrkL with procaspase-8 promotes cell migration.Protease activity of procaspase-8 is essential for cell survival by inhibiting both apoptotic and nonapoptotic cell death dependent on receptor-interacting protein kinase 1 (RIP1) and RIP3.The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8.FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity.Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell FateCaspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis.Molecular determinants involved in activation of caspase 7Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion.Activation and specificity of human caspase-10.BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane.Studies of the molecular mechanism of caspase-8 activation by solution NMR.Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3.Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases -3, -6, -7, & -8.Caspase-8 processing within TLR3 complexCaspase-8 processing within TLR4 complexCaspase-8 processing in the DISCCaspase-8 and FLIP(L) processing at DISCCaspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes.Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.Supramolecular Control of Enzyme Activity through Cucurbit[8]uril-Mediated Dimerization
P2860
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P2860
Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural and biochemical stu ...... n initiator caspase activation
@ast
Structural and biochemical stu ...... n initiator caspase activation
@en
Structural and biochemical stu ...... n initiator caspase activation
@nl
type
label
Structural and biochemical stu ...... n initiator caspase activation
@ast
Structural and biochemical stu ...... n initiator caspase activation
@en
Structural and biochemical stu ...... n initiator caspase activation
@nl
prefLabel
Structural and biochemical stu ...... n initiator caspase activation
@ast
Structural and biochemical stu ...... n initiator caspase activation
@en
Structural and biochemical stu ...... n initiator caspase activation
@nl
P2093
P3181
P1433
P1476
Structural and biochemical stu ...... n initiator caspase activation
@en
P2093
Jirí Mares
Markus G Grütter
Nadine Keller
Oliver Zerbe
P304
P3181
P356
10.1016/J.STR.2008.12.019
P577
2009-03-11T00:00:00Z