Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

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Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH Antiarrhythmic drug research PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels.A comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in mice.

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P2860

Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

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http://www.wikidata.org/entity/Q43264506

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2000 nî lūn-bûn

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2000年の論文

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年學術文章

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2000年學術文章

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Effects of a quaternary bupivacaine derivative on delayed rectifier K

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Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

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type

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label

Effects of a quaternary bupivacaine derivative on delayed rectifier K

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Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

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prefLabel

Effects of a quaternary bupivacaine derivative on delayed rectifier K

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Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

@en

P1476

Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

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P2093

M Longobardo

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M M Tamkun

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R Caballero

http://www.w3.org/2001/XMLSchema#string

R Navarro-Polanco

http://www.w3.org/2001/XMLSchema#string

T González

http://www.w3.org/2001/XMLSchema#string

P2860

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits

Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel

Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.

Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.

A permanent ion binding site located between two gates of the Shaker K+ channel.

The internal quaternary ammonium receptor site of Shaker potassium channels.

Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole.

A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression

Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels

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scholarly article

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10.1038/SJ.BJP.0703334

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English

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130

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1572085

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Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

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P2860

P2860

Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

description

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P1433

P1476

P2093

P2860

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P932