Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.
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Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor bindingPyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.Glutaminyl cyclases as novel targets for the treatment of septic arthritis.N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.Characterization of AβpN3 deposition in the brains of dogs of various ages and other animal species.A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.
P2860
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P2860
Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年學術文章
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name
Mammalian glutaminyl cyclases ...... cal enzymatic characteristics.
@en
Mammalian glutaminyl cyclases ...... cal enzymatic characteristics.
@nl
type
label
Mammalian glutaminyl cyclases ...... cal enzymatic characteristics.
@en
Mammalian glutaminyl cyclases ...... cal enzymatic characteristics.
@nl
prefLabel
Mammalian glutaminyl cyclases ...... cal enzymatic characteristics.
@en
Mammalian glutaminyl cyclases ...... cal enzymatic characteristics.
@nl
P2093
P2860
P1433
P1476
Mammalian glutaminyl cyclases ...... cal enzymatic characteristics.
@en
P2093
Alex von Bohlen
Anett Stephan
Birgit Koch
Hans-Ulrich Demuth
Michael Wermann
Stephan Schilling
P2860
P304
P356
10.1111/J.1742-4658.2009.07337.X
P407
P50
P577
2009-10-05T00:00:00Z