about
TREM2 in CNS homeostasis and neurodegenerative diseaseBeta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD)Genetic variants in Alzheimer disease - molecular and brain network approachesNeuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders.Neurobiology of Alzheimer's Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive DimensionsThe triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.Microglia: unique and common features with other tissue macrophages.Integrated approaches for analyzing U1-70K cleavage in Alzheimer's disease.Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's diseaseTemporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.Genomics in neurological disorders.microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular DegenerationApolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the ratEpigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.Microglial dysfunction in brain aging and Alzheimer's diseaseTREM2 in Alzheimer's disease.Phagocyte dysfunction, tissue aging and degeneration.The innate immune system in Alzheimer's disease.Amyloid-based immunotherapy for Alzheimer's disease in the time of prevention trials: the way forward.TYROBP in Alzheimer's disease.The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.Biomarkers in Sporadic and Familial Alzheimer's Disease.Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2).TREM2 in Neurodegenerative Diseases.Emerging pathways driving early synaptic pathology in Alzheimer's disease.Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits.Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development.Functional diversity of microglia - how heterogeneous are they to begin with?Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an updateUnraveling the genes implicated in Alzheimer's disease.Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study.Presence of severe neuroinflammation does not intensify neurofibrillary degeneration in human brain.Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.TREM2 signaling, miRNA-34a and the extinction of phagocytosis.TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice.Intracellular trafficking of TREM2 is regulated by presenilin 1.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Variant TREM2 as risk factor for Alzheimer's disease.
@en
Variant TREM2 as risk factor for Alzheimer's disease.
@nl
type
label
Variant TREM2 as risk factor for Alzheimer's disease.
@en
Variant TREM2 as risk factor for Alzheimer's disease.
@nl
prefLabel
Variant TREM2 as risk factor for Alzheimer's disease.
@en
Variant TREM2 as risk factor for Alzheimer's disease.
@nl
P356
P1476
Variant TREM2 as risk factor for Alzheimer's disease.
@en
P2093
Harald Neumann
P304
P356
10.1056/NEJME1213157
P407
P577
2012-11-14T00:00:00Z