Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). - Wikidata - wikimedia - TriplyDB

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

http://www.wikidata.org/entity/Q36283527

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Regulation of microglial survival and proliferation in health and diseases.Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.The endocytic pathway in microglia during health, aging and Alzheimer's disease.The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2.TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease Soluble TREM2 induces inflammatory responses and enhances microglial survival.TREM2 in Neurodegenerative Diseases.The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases TREM2-Ligand Interactions in Health and Disease.A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway The role of APOE on lipid homeostasis and inflammation in normal brains.Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins.Untangling Genetic Risk for Alzheimer's Disease.The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Intracellular trafficking of TREM2 is regulated by presenilin 1.Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage.Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer's Disease Pathology in Down Syndrome.The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.Microglia emerge as central players in brain disease.Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.Vps35-dependent recycling of Trem2 regulates microglial function.Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease.Differential contribution of microglia and monocytes in neurodegenerative diseases.Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.A transcriptomic atlas of aged human microglia.Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

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JBC.M115.679043

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Journal of Biological Chemistry

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Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).

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Chia-Chen Liu

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Christophe Verbeeck

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Guojun Bu

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Honghua Zheng

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Huaxi Xu

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John D Fryer

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Meghan M Painter

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Pritam Das

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Silvia S Kang

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Steven Younkin

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E

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26043-26050

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10.1074/JBC.M115.679043

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2015-09-15T00:00:00Z

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