Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.
about
Layilin, a novel integral membrane protein, is a hyaluronan receptorThe tumor-suppressor function of E-cadherinInsulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expressionAntiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisGhrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted miceBrivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibitionJunctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose toleranceThe potential role of podoplanin in tumour invasionBenefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitorsOpenings between defective endothelial cells explain tumor vessel leakinessSub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancerPodoplanin - a small glycoprotein with many facesFrom targets to treatments: a review of molecular targets in pancreatic neuroendocrine tumorsRebuilding cancer metastasis in the mouseConcise review: in search of unlimited sources of functional human pancreatic beta cellsGenetically engineered mouse models of pancreatic adenocarcinomaMouse models for studying angiogenesis and lymphangiogenesis in cancerData mining strategies to improve multiplex microbead immunoassay tolerance in a mouse model of infectious diseasesGranuphilin exclusively mediates functional granule docking to the plasma membrane.Myeloid cells contribute to tumor lymphangiogenesisGenetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancerGenetically engineered mouse models in oncology research and cancer medicineIsolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expressionSILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markersMatrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisVascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis.Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitorsDeletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancerEarly regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic miceFrom bench to bedside: lessons learned in translating preclinical studies in cancer drug developmentPax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancerNeuroD is required for differentiation of the granule cells in the cerebellum and hippocampusRibozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretionModulation of L-selectin ligand expression during an immune response accompanying tumorigenesis in transgenic miceExpression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis.Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma.Resistance to targeted therapies in pancreatic neuroendocrine tumors (PNETs): molecular basis, preclinical data, and counteracting strategies.
P2860
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P2860
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh-hant
name
Heritable formation of pancrea ...... lin/simian virus 40 oncogenes.
@en
Heritable formation of pancrea ...... lin/simian virus 40 oncogenes.
@nl
type
label
Heritable formation of pancrea ...... lin/simian virus 40 oncogenes.
@en
Heritable formation of pancrea ...... lin/simian virus 40 oncogenes.
@nl
prefLabel
Heritable formation of pancrea ...... lin/simian virus 40 oncogenes.
@en
Heritable formation of pancrea ...... lin/simian virus 40 oncogenes.
@nl
P356
P1433
P1476
Heritable formation of pancrea ...... lin/simian virus 40 oncogenes.
@en
P2093
P2888
P304
P356
10.1038/315115A0
P407
P577
1985-05-01T00:00:00Z
P6179
1034094925