T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.
about
CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristicsCrystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC moleculeT cell antigen recognition at the cell membraneAffinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complexCrystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagementA role for rebinding in rapid and reliable T cell responses to antigenO-glycan sialylation and the structure of the stalk-like region of the T cell co-receptor CD8.TCR signal initiation machinery is pre-assembled and activated in a subset of membrane raftsCD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.Piecing together the family portrait of TCR-CD3 complexes.Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRsA Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 DimerizationStage-dependent reactivity of thymocytes to self-peptide--MHC complexes.TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Weak self-association in a carbohydrate systemAnalysis of serial engagement and peptide-MHC transport in T cell receptor microclustersInteraction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer.Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology.Structural and biophysical insights into the role of CD4 and CD8 in T cell activation.Class II major histocompatibility complex tetramer staining: progress, problems, and prospects.Low-affinity CD4+ T cells are major responders in the primary immune responseThe structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset CommitmentCodification of bidentate pMHC interaction with TCR and its co-receptor.Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand.Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.Expression, purification, and characterization of recombinant HIV gp140. The gp41 ectodomain of HIV or simian immunodeficiency virus is sufficient to maintain the retroviral envelope glycoprotein as a trimer.Understanding the Functional Roles of Multiple Extracellular Domains in Cell Adhesion Molecules with a Coarse-Grained Model.The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.
P2860
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P2860
T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
@zh
2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-my
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@zh-hant
name
T Cell Receptor Binding to a p ...... t from and Independent of CD4.
@en
T Cell Receptor Binding to a p ...... t from and Independent of CD4.
@nl
type
label
T Cell Receptor Binding to a p ...... t from and Independent of CD4.
@en
T Cell Receptor Binding to a p ...... t from and Independent of CD4.
@nl
prefLabel
T Cell Receptor Binding to a p ...... t from and Independent of CD4.
@en
T Cell Receptor Binding to a p ...... t from and Independent of CD4.
@nl
P2093
P2860
P356
P1476
T Cell Receptor Binding to a p ...... t from and Independent of CD4.
@en
P2093
P2860
P304
P356
10.1074/JBC.M009580200
P407
P577
2000-12-05T00:00:00Z