CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. - Wikidata - wikimedia - TriplyDB

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.

http://www.wikidata.org/entity/Q44973640

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SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics Quantitative challenges in understanding ligand discrimination by alphabeta T cells The quantal theory of how the immune system discriminates between "self and non-self"Modeling T cell antigen discrimination based on feedback control of digital ERK responses Aurora A drives early signalling and vesicle dynamics during T-cell activation.Emergent dynamics of thymocyte development and lineage determination Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4 Recent advances in T-cell engineering for use in immunotherapy Computational investigations into the origins of short-term biochemical memory in T cell activation Phosphorylation site dynamics of early T-cell receptor signaling CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection T cell receptor bias for MHC: co-evolution or co-receptors?Memory in receptor-ligand-mediated cell adhesion Regulated movement of CD4 in and out of the immunological synapse Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.A role for rebinding in rapid and reliable T cell responses to antigen Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.Attenuated T cell responses to a high-potency ligand in vivo.Perspectives for computer modeling in the study of T cell activation Tandem fluorescence imaging of dynamic S-acylation and protein turnover.TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function Rules for modeling signal-transduction systems.Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response Tuning immune responses: diversity and adaptation of the immunological synapse.The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15 T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes.

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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.

http://www.wikidata.org/entity/Q44973640

description

2004 nî lūn-bûn

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CD4 enhances T cell sensitivit ...... at the immunological synapse.

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CD4 enhances T cell sensitivit ...... at the immunological synapse.

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CD4 enhances T cell sensitivit ...... at the immunological synapse.

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Nature Immunology

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CD4 enhances T cell sensitivit ...... at the immunological synapse.

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Aaron R Dinner

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Arup K Chakraborty

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Darrell J Irvine

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Johannes B Huppa

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Mark M Davis

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Qi-Jing Li

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Shuyan Qi

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P2860

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

Role of CD4 and CD8 in T cell activation and differentiation

CD4 dimers constitute the functional component required for T cell activation

Dimeric association and segmental variability in the structure of human CD4

Interaction between CD4 and class II MHC molecules mediates cell adhesion

Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated

An amplified sensitivity arising from covalent modification in biological systems

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

The immunological synapse: a molecular machine controlling T cell activation

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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