Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property.
about
Mechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa ActivityDisulfide locked variants of factor VIIa with a restricted beta-strand conformation have enhanced enzymatic activityRational design of coagulation factor VIIa variants with substantially increased intrinsic activity.Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa ActivityDesign and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients.Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement.Factor VII mutant V154G models a zymogen-like form of factor VIIa.A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates.A loop of coagulation factor VIIa influencing macromolecular substrate specificity
P2860
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P2860
Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property.
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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2001年学术文章
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name
Factor VIIa modified in the 17 ...... nge the zymogen-like property.
@en
Factor VIIa modified in the 17 ...... nge the zymogen-like property.
@nl
type
label
Factor VIIa modified in the 17 ...... nge the zymogen-like property.
@en
Factor VIIa modified in the 17 ...... nge the zymogen-like property.
@nl
prefLabel
Factor VIIa modified in the 17 ...... nge the zymogen-like property.
@en
Factor VIIa modified in the 17 ...... nge the zymogen-like property.
@nl
P2093
P2860
P356
P1476
Factor VIIa modified in the 17 ...... nge the zymogen-like property.
@en
P2093
P2860
P304
17229-17235
P356
10.1074/JBC.M009206200
P407
P577
2001-02-02T00:00:00Z