Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase.
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Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesisThe molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersDecreased androgen levels and improved menstrual pattern after angiotensin II receptor antagonist telmisartan treatment in four hypertensive patients with polycystic ovary syndrome: case seriesProtein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cellsEffect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studiesInsulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.In polycystic ovary syndrome, adrenal steroids are regulated differently in the morning versus in response to nutrient intake.Similar causes of various reproductive disorders in early lifeEffects of thiazolidinediones on bone loss and fracture.Thiazolidinedione use and bone loss in older diabetic adults.Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients.Genetic variants in peroxisome proliferator-activated receptor gamma influence insulin resistance and testosterone levels in normal women, but not those with polycystic ovary syndromeGenetics of polycystic ovary syndrome: searching for the way out of the labyrinth.Role of metformin in the management of polycystic ovary syndrome.Weight reduction and pioglitazone ameliorate polycystic ovary syndrome after removal of a Sertoli-stromal cell tumorPPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility.Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice.Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine.Targets to treat metabolic syndrome in polycystic ovary syndromePhosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis.Metabolic and hormonal changes induced by pioglitazone in polycystic ovary syndrome: a randomized, placebo-controlled clinical trial.New and emerging treatments in dermatology: acne.Activation of PPARγ by Rosiglitazone does not negatively impact male sex steroid hormones in diabetic rats.Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeysDiabetes and fracture healing: the skeletal effects of diabetic drugs.Effect of protracted treatment with rosiglitazone, a PPARgamma agonist, in patients with Cushing's disease.Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans.Troglitazone: a possible modulator of ovarian steroidogenesis.Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2.Effect of pioglitazone on testosterone in eugonadal men with type 2 diabetes mellitus: a randomized double-blind placebo-controlled study.The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome.The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.Endocrine-metabolic effects of the treatment with pioglitazone in obese patients with polycystic ovary syndrome.The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome.Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study.Modulating Intrafollicular Hormonal Milieu in Controlled Ovarian Stimulation: Insights From PPAR Expression in Human Granulosa Cells.Add on DPP-4 inhibitor alogliptin alone or in combination with pioglitazone improved β-cell function and insulin sensitivity in metformin treated PCOS.
P2860
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P2860
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Thiazolidinediones but not met ...... -hydroxysteroid dehydrogenase.
@en
Thiazolidinediones but not met ...... -hydroxysteroid dehydrogenase.
@nl
type
label
Thiazolidinediones but not met ...... -hydroxysteroid dehydrogenase.
@en
Thiazolidinediones but not met ...... -hydroxysteroid dehydrogenase.
@nl
prefLabel
Thiazolidinediones but not met ...... -hydroxysteroid dehydrogenase.
@en
Thiazolidinediones but not met ...... -hydroxysteroid dehydrogenase.
@nl
P2860
P356
P1476
Thiazolidinediones but not met ...... -hydroxysteroid dehydrogenase.
@en
P2093
R J Auchus
W L Miller
P2860
P304
16767-16771
P356
10.1074/JBC.M100040200
P407
P50
P577
2001-02-07T00:00:00Z