p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production.
about
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activationInteraction of calmodulin with Sec61α limits Ca2+ leakage from the endoplasmic reticulum.Stochastic modeling of calcium in 3D geometry.Reaction diffusion modeling of calcium dynamics with realistic ER geometryBlockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TATHigh resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo.The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.IgE-dependent signaling as a therapeutic target for allergies.Mutations in the inter-SH2 domain of the regulatory subunit of phosphoinositide 3-kinase: effects on catalytic subunit binding and holoenzyme function.Single-cell analysis of phosphoinositide 3-kinase and phosphatase and tensin homolog activationSpecific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts.Distinct phosphoinositide 3-kinases mediate mast cell degranulation in response to G-protein-coupled versus FcepsilonRI receptors.Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase.Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics.Differential involvement of phosphoinositide 3-kinase in gonadotrophin-releasing hormone actions in gonadotrophs and somatotrophs of goldfish, Carassius auratus.
P2860
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P2860
p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
p110beta and p110delta phospha ...... ,4,5-trisphosphate production.
@en
p110beta and p110delta phospha ...... ,4,5-trisphosphate production.
@nl
type
label
p110beta and p110delta phospha ...... ,4,5-trisphosphate production.
@en
p110beta and p110delta phospha ...... ,4,5-trisphosphate production.
@nl
prefLabel
p110beta and p110delta phospha ...... ,4,5-trisphosphate production.
@en
p110beta and p110delta phospha ...... ,4,5-trisphosphate production.
@nl
P2093
P2860
P356
P1476
p110beta and p110delta phospha ...... 1,4,5-trisphosphate production
@en
P2093
B S Wilson
E A Gaudet
J M Backer
Z Surviladze
P2860
P304
17213-17220
P356
10.1074/JBC.M100417200
P407
P577
2001-02-15T00:00:00Z