The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
about
A beta version of life: p110β takes center stageShould individual PI3 kinase isoforms be targeted in cancer?Cardiac regulation by phosphoinositide 3-kinases and PTENG protein betagamma subunits regulate cell adhesion through Rap1a and its effector RadilG-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT SignalingPhosphoinositide 3-kinase: friend and foe in cardiovascular diseaseS1PR2 links germinal center confinement and growth regulationTargeting G protein coupled receptor-related pathways as emerging molecular therapiesPhosphoinositides: tiny lipids with giant impact on cell regulationRegulation of platelet plug formation by phosphoinositide metabolismStatus of PI3K/Akt/mTOR pathway inhibitors in lymphomaIncreased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory MechanismThe p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Signaling by the phosphoinositide 3-kinase family in immune cellsInhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoformsPI3K at the crossroads of tumor angiogenesis signaling pathwaysNovel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli CellsBJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX PathwayPhosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cellsInsulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cellsRas is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gammaTargeting the phosphoinositide 3-kinase pathway in cancerDynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.Regulation of p110delta PI 3-kinase gene expression.PI3Kgamma-dependent signaling in mouse olfactory receptor neurons.Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatusThe Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug designInhibitory odorant signaling in Mammalian olfactory receptor neurons.PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.Puquitinib, a novel orally available PI3Kδ inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemiaA constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.Activity of any class IA PI3K isoform can sustain cell proliferation and survival.
P2860
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P2860
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The p110beta isoform of phosph ...... ally redundant with p110gamma.
@en
type
label
The p110beta isoform of phosph ...... ally redundant with p110gamma.
@en
prefLabel
The p110beta isoform of phosph ...... ally redundant with p110gamma.
@en
P2093
P2860
P50
P356
P1476
The p110beta isoform of phosph ...... nally redundant with p110gamma
@en
P2093
Andrew J H Smith
Ashreena Salpekar
Bart Vanhaesebroeck
Cristiano Gonella
Katja Bjorklof
Stephen Meek
P2860
P304
P356
10.1073/PNAS.0707761105
P407
P577
2008-06-10T00:00:00Z