The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
about
Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase IIViral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide DepletionFunctional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activityAlphavirus RNA synthesis and non-structural protein functionsIntrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triadHigh-resolution functional mapping of the venezuelan equine encephalitis virus genome by insertional mutagenesis and massively parallel sequencingEnzymatic Defects of the nsP2 Proteins of Semliki Forest Virus Temperature-Sensitive MutantsDevelopment of Sindbis Viruses Encoding nsP2/GFP Chimeric Proteins and Their Application for Studying nsP2 FunctioningIRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cellsMolecular cloning, overproduction, purification and biochemical characterization of the p39 nsp2 protease domains encoded by three alphavirusesA structural and functional perspective of alphavirus replication and assemblyStructural and functional insights into alphavirus polyprotein processing and pathogenesisStructural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMPA Compact Viral Processing Proteinase/Ubiquitin Hydrolase from the OTU FamilyKinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine ProteaseDiscovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcriptionStructural basis for substrate specificity of alphavirus nsP2 proteases.Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinaseFull length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates.Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine.Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection.Role for subgenomic mRNA in host translation inhibition during Sindbis virus infection of mammalian cells.Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis.Design and Validation of Novel Chikungunya Virus Protease Inhibitors.Inhibition of host protein synthesis by Sindbis virus: correlation with viral RNA replication and release of nuclear proteins to the cytoplasm.Structure-function relationship of Chikungunya nsP2 protease: A comparative study with papain.Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication.Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component.Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein.A new role for ns polyprotein cleavage in Sindbis virus replication.Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.Conformer and pharmacophore based identification of peptidomimetic inhibitors of chikungunya virus nsP2 protease.Nuclear import and export of Venezuelan equine encephalitis virus nonstructural protein 2.Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.The Regulation of Translation in Alphavirus-Infected Cells.Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virus Nucleocapsid and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication.The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral StrategiesBiodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication
P2860
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P2860
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
@en
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
@nl
type
label
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
@en
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
@nl
prefLabel
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
@en
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
@nl
P1433
P1476
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
@en
P2093
Andrew T Russo
Stanley J Watowich
P304
P356
10.1016/J.STR.2006.07.010
P577
2006-09-01T00:00:00Z