Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
about
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's diseaseIdentification of distant drug off-targets by direct superposition of binding pocket surfacesPhosphodiesterase 5 inhibitors: current status and potential applications.Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations.Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity3-(3-Bromo-benz-yl)isoquinolin-1(2H)-one.Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.
P2860
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P2860
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
@zh-hans
2001年学术文章
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2001年学术文章
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2001年學術文章
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2001年學術文章
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name
Novel, potent, and selective p ...... -1-isoquinolinone derivatives.
@en
Novel, potent, and selective p ...... -1-isoquinolinone derivatives.
@nl
type
label
Novel, potent, and selective p ...... -1-isoquinolinone derivatives.
@en
Novel, potent, and selective p ...... -1-isoquinolinone derivatives.
@nl
prefLabel
Novel, potent, and selective p ...... -1-isoquinolinone derivatives.
@en
Novel, potent, and selective p ...... -1-isoquinolinone derivatives.
@nl
P2093
P356
P1476
Novel, potent, and selective p ...... -1-isoquinolinone derivatives.
@en
P2093
Higashijima T
Moritani Y
Nakamura Y
P304
P356
10.1021/JM000558H
P407
P577
2001-06-01T00:00:00Z