Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
about
Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicingModulating splicing with small molecular inhibitors of the spliceosomeConnecting the speckles: Splicing kinases and their role in tumorigenesis and treatment responsePhosphorylation-mediated regulation of alternative splicing in cancerEvaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural ApproachesDiscovery of a splicing regulator required for cell cycle progressionSpliceosome Structure and FunctionUSP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis methodSpliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa.A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome ActivationFgPrp4 Kinase Is Important for Spliceosome B-Complex Activation and Splicing Efficiency in Fusarium graminearum.ATPγS stalls splicing after B complex formation but prior to spliceosome activation.PRP4K is a HER2-regulated modifier of taxane sensitivity.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site.How gene expression in fast-proliferating cells keeps pace.Pharmacology of Modulators of Alternative Splicing.A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activityhnRNP L and hnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly.Diversity, classification and function of the plant protein kinase superfamily.Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking.Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function.
P2860
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P2860
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Human PRP4 kinase is required ...... iceosomal B complex formation.
@en
Human PRP4 kinase is required ...... iceosomal B complex formation.
@nl
type
label
Human PRP4 kinase is required ...... iceosomal B complex formation.
@en
Human PRP4 kinase is required ...... iceosomal B complex formation.
@nl
prefLabel
Human PRP4 kinase is required ...... iceosomal B complex formation.
@en
Human PRP4 kinase is required ...... iceosomal B complex formation.
@nl
P2093
P2860
P356
P1476
Human PRP4 kinase is required ...... iceosomal B complex formation.
@en
P2093
He-Hsuan Hsiao
Henning Urlaub
Marc Schneider
Régis Giet
P2860
P2888
P304
P356
10.1038/NSMB.1718
P577
2010-01-31T00:00:00Z