sameAs
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.HSPC117 is the essential subunit of a human tRNA splicing ligase complexThe human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosomeIdentification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferaseA subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicingIdentification of novel argonaute-associated proteinsRNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoproteinsComposition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexesRNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodiesThe human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosomeMolecular architecture of the human Prp19/CDC5L complexHuman U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recyclingCwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centreBinding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNPThe crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP proteinDynamic protein-protein interaction wiring of the human spliceosomeCharacterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box proteinCoupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy proteinFunctional organization of the Sm core in the crystal structure of human U1 snRNPProtein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometryMinor spliceosome components are predominantly localized in the nucleusUnique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processingOngoing U snRNP biogenesis is required for the integrity of Cajal bodiesStructural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteinsA role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNPMammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexesThe human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.The network of protein-protein interactions within the human U4/U6.U5 tri-snRNPRole of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNPStructure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopyTwo protein-protein interaction sites on the spliceosome-associated human cyclophilin CypHThe Prp19 complex directly functions in mitotic spindle assemblyA stochastic view of spliceosome assembly and recycling in the nucleusCrystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptideStructure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosaStructural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)Structure and function of an RNase H domain at the heart of the spliceosome
P50
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P50
description
Duits biochemicus
@nl
German biochemist
@en
bithchemiceoir Gearmánach
@ga
deutscher Biochemiker
@de
professor académico alemão
@pt
tysk professor
@da
tysk professor
@sv
name
Reinhard Georg Lührmann
@en
Reinhard Georg Lührmann
@es
Reinhard Georg Lührmann
@sl
Reinhard Lührmann
@ca
Reinhard Lührmann
@da
Reinhard Lührmann
@de
Reinhard Lührmann
@fr
Reinhard Lührmann
@nb
Reinhard Lührmann
@nds
Reinhard Lührmann
@nl
type
label
Reinhard Georg Lührmann
@en
Reinhard Georg Lührmann
@es
Reinhard Georg Lührmann
@sl
Reinhard Lührmann
@ca
Reinhard Lührmann
@da
Reinhard Lührmann
@de
Reinhard Lührmann
@fr
Reinhard Lührmann
@nb
Reinhard Lührmann
@nds
Reinhard Lührmann
@nl
altLabel
Reinhard Lührmann
@en
prefLabel
Reinhard Georg Lührmann
@en
Reinhard Georg Lührmann
@es
Reinhard Georg Lührmann
@sl
Reinhard Lührmann
@ca
Reinhard Lührmann
@da
Reinhard Lührmann
@de
Reinhard Lührmann
@fr
Reinhard Lührmann
@nb
Reinhard Lührmann
@nds
Reinhard Lührmann
@nl
P108
P166
P214
P227
P244
P269
P1412
P1559
Reinhard Lührmann
@de
P166
P19
P21
P213
0000 0003 5845 4868
P214
P227
P244
nb2012002725