Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
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Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthasesBinding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimerMolecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium ParasitesA critical review on Chagas disease chemotherapyChemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasisSynergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruziBisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme dataMetabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii.In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.Risedronate metal complexes potentially active against Chagas disease.Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.Promising therapeutic targets for antileishmanial drugs.Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera.The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase.Novel antitrypanosomal agents.1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthaseSingle-target high-throughput transcription analyses reveal high levels of alternative splicing present in the FPPS/GGPPS from Plasmodium falciparum.Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthaseDesign, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei.Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparumAnti-infectives targeting the isoprenoid pathway of Toxoplasma gondii.The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites.Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni.New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.Potential new clinical therapies for Chagas disease.Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate.Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA.Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells.Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies.How myeloma cells escape bisphosphonate-mediated killing: development of specific resistance with preserved sensitivity to conventional chemotherapeutics.The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.Low-energy conformers of pamidronate and their intramolecular hydrogen bonds: a DFT and QTAIM study.Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats.A solanesyl-diphosphate synthase localizes in glycosomes of Trypanosoma cruzi.A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice.
P2860
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P2860
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Bisphosphonates are potent inh ...... rnesyl pyrophosphate synthase.
@en
Bisphosphonates are potent inh ...... rnesyl pyrophosphate synthase.
@nl
type
label
Bisphosphonates are potent inh ...... rnesyl pyrophosphate synthase.
@en
Bisphosphonates are potent inh ...... rnesyl pyrophosphate synthase.
@nl
prefLabel
Bisphosphonates are potent inh ...... rnesyl pyrophosphate synthase.
@en
Bisphosphonates are potent inh ...... rnesyl pyrophosphate synthase.
@nl
P2093
P2860
P356
P1476
Bisphosphonates are potent inh ...... rnesyl pyrophosphate synthase.
@en
P2093
Montalvetti A
Oldfield E
P2860
P304
33930-33937
P356
10.1074/JBC.M103950200
P407
P577
2001-07-02T00:00:00Z