Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
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tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humansCarboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosisIncreased islet apoptosis in Pdx1+/- miceIslet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.Effects of narrow band UVB (311 nm) irradiation on epidermal cellsExploring the metabolic syndrome: Nonalcoholic fatty pancreas diseaseGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimPPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunctionUbiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosisTRB3 is involved in free fatty acid-induced INS-1-derived cell apoptosis via the protein kinase C δ pathwayProtein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosisEndoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development.Glucolipotoxicity of the pancreatic beta cell.Palmitate impairs angiogenesis via suppression of cathepsin activityFatty acids from very low-density lipoprotein lipolysis products induce lipid droplet accumulation in human monocytes.Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity.Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.Sphingolipids in obesity, type 2 diabetes, and metabolic disease.Effects of high-fat diet and the anti-diabetic drug metformin on circulating GLP-1 and the relative number of intestinal L-cells.Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats.Adipose differentiation-related protein regulates lipids and insulin in pancreatic isletsObese rats exhibit high levels of fat necrosis and isoprostanes in taurocholate-induced acute pancreatitis.Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms.Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity.Islet beta cell failure in type 2 diabetesEffects of free fatty acids on insulin secretion in obesity.Triglyceride accumulation protects against fatty acid-induced lipotoxicity.Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.Enteric neuropathy can be induced by high fat diet in vivo and palmitic acid exposure in vitro.Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level.Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition.Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and up-regulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: is that a latent disadvantage?Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.
P2860
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P2860
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Inverse relationship between c ...... lar triglyceride accumulation.
@en
Inverse relationship between c ...... lar triglyceride accumulation.
@nl
type
label
Inverse relationship between c ...... lar triglyceride accumulation.
@en
Inverse relationship between c ...... lar triglyceride accumulation.
@nl
prefLabel
Inverse relationship between c ...... lar triglyceride accumulation.
@en
Inverse relationship between c ...... lar triglyceride accumulation.
@nl
P2093
P1433
P1476
Inverse relationship between c ...... ular triglyceride accumulation
@en
P2093
D G Pipeleers
D L Eizirik
J C Hannaert
P304
P356
10.2337/DIABETES.50.8.1771
P407
P50
P577
2001-08-01T00:00:00Z