Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
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Statins and cancersMevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible LinkThe potential effect of statins on rituximab immunotherapy.Tumor macroenvironment and metabolism.Effects of lovastatin on breast cancer cells: a proteo-metabonomic study.P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype.Anti-angiogenic and anti-inflammatory effects of statins: relevance to anti-cancer therapyTargeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells.Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells.Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomasAssociation between statin use and cancer: data mining of a spontaneous reporting database and a claims database.Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia.Statins use and the risk of all and subtype hematological malignancies: a meta-analysis of observational studiesJAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.The mevalonate pathway during acute tubular injury: selected determinants and consequences.Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study.Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activationUse of statins and risk of haematological malignancies: a meta-analysis of six randomized clinical trials and eight observational studies.Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiationMevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models.Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.Statin use and cancer risk: an epidemiologic review.Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hoursStatins inhibit the proliferation and induce cell death of human papilloma virus positive and negative cervical cancer cells.Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascadeEffect of simvastatin on glioma cell proliferation, migration, and apoptosisStatin use is associated with reduced risk of haematological malignancies: evidence from a meta-analysis.Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.Microbial production and biomedical applications of lovastatin.Antileukemic properties of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.HMG-CoA reductase inhibitors as adjuvant treatment for hematologic malignancies: what is the current evidence?Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines.Cancer risk among statin users: a population-based cohort study.Immune regulatory effects of simvastatin on regulatory T cell-mediated tumour immune tolerance.Exploitation of pleiotropic actions of statins by using tumour-targeted delivery systems.The interplay between cell signalling and the mevalonate pathway in cancer.Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition.Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.
P2860
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P2860
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Blocking protein geranylgerany ...... acute myeloid leukemia cells.
@en
Blocking protein geranylgerany ...... acute myeloid leukemia cells.
@nl
type
label
Blocking protein geranylgerany ...... acute myeloid leukemia cells.
@en
Blocking protein geranylgerany ...... acute myeloid leukemia cells.
@nl
prefLabel
Blocking protein geranylgerany ...... acute myeloid leukemia cells.
@en
Blocking protein geranylgerany ...... acute myeloid leukemia cells.
@nl
P2093
P356
P1433
P1476
Blocking protein geranylgerany ...... acute myeloid leukemia cells.
@en
P2093
P2888
P304
P356
10.1038/SJ.LEU.2402196
P50
P577
2001-09-01T00:00:00Z
P5875
P6179
1005566498