Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.
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The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide SynthasesMonomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytesAccelerated ubiquitination and proteasome degradation of a genetic variant of inducible nitric oxide synthaseSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamProbing heme coordination states of inducible nitric oxide synthase with a ReI(imidazole-alkyl-nitroarginine) sensitizer-wireRegulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors.Nitric oxide blocks cellular heme insertion into a broad range of heme proteinsVisualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor.Elevated incidence of polyp formation in APC(Min/⁺)Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutationsThe bioinorganic chemistry of iron in oxygenases and supramolecular assemblies.Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumoniaHsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process.Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease.The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus.The role of nitric oxide in osteoarthritis.Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.The complex role of iNOS in acutely rejecting cardiac transplants.Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injuryMechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma.Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription.Identification of iNOS inhibitors using InteraX.Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III.Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury.The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury.Thermodynamics of strongly allosteric inhibition: a model study of HIV-1 protease
P2860
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P2860
Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Mechanistic studies with poten ...... thase dimerization inhibitors.
@en
Mechanistic studies with poten ...... thase dimerization inhibitors.
@nl
type
label
Mechanistic studies with poten ...... thase dimerization inhibitors.
@en
Mechanistic studies with poten ...... thase dimerization inhibitors.
@nl
prefLabel
Mechanistic studies with poten ...... thase dimerization inhibitors.
@en
Mechanistic studies with poten ...... thase dimerization inhibitors.
@nl
P2093
P356
P1476
Mechanistic studies with poten ...... thase dimerization inhibitors.
@en
P2093
Charles B Glaser
Dennis J Stuehr
Douglas S Auld
Eric Blasko
Gary B Phillips
James J Devlin
John F Parkinson
Kirk McMillan
Marc Whitlow
Mark A Polokoff
P304
P356
10.1074/JBC.M105691200
P407
P577
2001-10-31T00:00:00Z