Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.
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alpha-Synuclein and neuronal cell deathInterplay of LRRK2 with chaperone-mediated autophagyDopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagyNuclear genes involved in mitochondria-to-nucleus communication in breast cancer cellsEndoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatmentThe Function of Autophagy in Neurodegenerative DiseasesΑlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's DiseaseRedox control of protein degradationDeconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purposeThe unfolded protein response in neurodegenerative diseases: a neuropathological perspectiveThe role of autophagy in Parkinson's diseaseProtein degradation pathways in Parkinson's disease: curse or blessingParkinson's disease as a result of agingAutophagosome dynamics in neurodegeneration at a glanceDegradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neuronsRepression of alpha-synuclein expression and toxicity by microRNA-7.Autophagy gone awry in neurodegenerative diseasesAutophagy in cell death: an innocent convict?Autophagy in health and disease: a double-edged swordER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy.TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.Partial correction of the CNS lysosomal storage defect in a mouse model of juvenile neuronal ceroid lipofuscinosis by neonatal CNS administration of an adeno-associated virus serotype rh.10 vector expressing the human CLN3 gene.Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases.Alterations in ROS activity and lysosomal pH account for distinct patterns of macroautophagy in LINCL and JNCL fibroblasts.Role of the ubiquitin proteasome system in Parkinson's disease.Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagyThe first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast.Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesSelective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathyNeuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death.Studying protein degradation pathways in vivo using a cranial window-based approach.Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behaviorLysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionBaicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity
P2860
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P2860
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Expression of A53T mutant but ...... se, and autophagic cell death.
@en
Expression of A53T mutant but ...... se, and autophagic cell death.
@nl
type
label
Expression of A53T mutant but ...... se, and autophagic cell death.
@en
Expression of A53T mutant but ...... se, and autophagic cell death.
@nl
prefLabel
Expression of A53T mutant but ...... se, and autophagic cell death.
@en
Expression of A53T mutant but ...... se, and autophagic cell death.
@nl
P2093
P1476
Expression of A53T mutant but ...... ase, and autophagic cell death
@en
P2093
H J Rideout
K E Larsen
L A Greene
L Stefanis
P304
P356
10.1523/JNEUROSCI.21-24-09549.2001
P407
P577
2001-12-01T00:00:00Z