A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer.
about
Li-fraumeni syndromeStructural evolution of p53, p63, and p73: Implication for heterotetramer formationDynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge networkTracing the evolution of the p53 tetramerization domainThe divergence, actions, roles, and relatives of sodium-coupled bicarbonate transportersThe implications of familial incidental findings from exome sequencing: the NIH Undiagnosed Diseases Program experienceSynthetic ligands able to interact with the p53 tetramerization domain. Towards understanding a protein surface recognition event.Noncanonical DNA motifs as transactivation targets by wild type and mutant p53Association of the germline TP53 R337H mutation with breast cancer in southern Brazil.Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical TumorThe p53 core domain is a molten globule at low pH: functional implications of a partially unfolded structure.The profile and contribution of rare germline copy number variants to cancer risk in Li-Fraumeni patients negative for TP53 mutations.Childhood adrenocortical tumours: a review.Prevalence of the TP53 p.R337H mutation in breast cancer patients in BrazilAltered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child: evidence for chimerism involving a common mutant founder haplotype: case report.Regional analysis of p53 mutations in rheumatoid arthritis synoviumIncreased oxidative damage in carriers of the germline TP53 p.R337H mutationCancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivationInfrequent tumor initiative of the Children's Oncology Group: initial lessons learned and their impact on future plansTP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient.Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.Pediatric adrenocortical tumors: what they can tell us on adrenal development and comparison with adult adrenal tumors.TP53-Associated Pediatric Malignancies.Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis.Challenging issues in pediatric oncologyTowards an understanding of the role of p53 in adrenocortical carcinogenesis.Occurrence of Neuroblastoma among TP53 p.R337H Carriers.Alterations of intracellular pH homeostasis in apoptosis: origins and roles.DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations.Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study.Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations.Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils.Number of rare germline CNVs and TP53 mutation types.Adrenocortical tumorigenesis.Intracellular pH sensors: design principles and functional significance.Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand.Activation and control of p53 tetramerization in individual living cellsCariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research.
P2860
Q22241780-20EB91E4-7968-455F-AE98-6D9ABE0AF003Q27657730-0BF7BE7F-419C-44FE-ACC5-9A517DB07D60Q28484775-2D647082-FD90-4FDF-9D6B-D8DA87663235Q28656003-A571C119-813F-476A-AC0A-0EE2E5A5F9B0Q30440948-82B76474-7F3E-488D-BEBC-2D467193B655Q30590291-11BF4788-BB8F-4D8F-BC9F-4F2C415B9658Q33247742-0746A974-2CC4-46AC-A8B9-5B98128CE22EQ33361623-1F416763-5524-4E33-BA4F-01A114EF5AE2Q33388533-65C2E415-C18A-48DD-A09B-1B7734E79C69Q33520529-21F517F1-ADF3-4740-A5CB-9DCB2C78AD8EQ33557391-68232150-D386-498B-B465-CE3A8F71C61DQ33594094-5599EAD2-2656-4F5D-BDA8-A3217057F611Q33615771-589C29D7-B56D-4AB9-B510-4ED68534CAB6Q33722503-E6DF4633-2D6B-4399-A93E-6425D7936503Q33768942-93B3EA1F-47C8-4987-94CF-A4FA83E711EAQ33865095-B998CEFD-D3CB-4542-84C2-687DEE3545E1Q34049523-4BBE3F18-6BF4-40EC-B54A-4E4DD963FE98Q34098828-509E1C0C-C23F-4F71-8F1A-62F557FF45E9Q34442664-50BF49E0-3742-475F-9BCA-E9A0AF3ECCE2Q34452519-6271AFFB-FB6B-498E-B5BC-508209CB2B02Q34488734-17539EB4-FD4C-4B42-81D0-CF87FD6FEA50Q34660470-50589557-7DA0-4847-9DC1-40B82BFFC3EBQ34986145-841289AB-F897-4AA0-8335-00D66FF608ABQ35094565-A831BFE5-6A2E-4599-A796-D191608EF1D7Q35103165-0EB4465D-BC84-44B5-87E4-4F4EE73697AEQ35561019-EC10FA89-CBC9-4F6E-AAFA-0360B85D0118Q35602419-2A54B904-F610-4E9A-8C89-734E68DCDA90Q35783751-9101DA8C-CB53-4A41-9AFD-87921463308DQ35801794-48655651-5A63-427A-849B-8294BF7AD2FEQ35803867-29625A24-3EC1-43F0-AB72-4B4CB1DCA2EEQ35881338-E8AE26A4-CF35-4571-8A0E-DA0DAB8D4708Q35896015-CDF40F23-3452-4FAA-849B-4161884FBD87Q36359653-6DEF8FE1-8246-4F3C-A578-B132ABB0414DQ36476636-7907B6E9-0D4D-4827-981F-079AAC668DE5Q36572009-0B1200F4-01C4-466D-A112-500897186F03Q36694025-68FB3F33-C496-4978-8E55-C28A695316EDQ36731993-D4B79941-FB6B-458B-86C0-51CCFE3A296DQ36954828-CE1F0121-2D98-46C2-ADF1-4B2B4C5373B7Q37191770-5EE1118D-0108-42ED-B89B-45D89BEE73FEQ37304956-C9FD204C-5868-4821-AD4A-4542DA444E00
P2860
A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
A novel mechanism of tumorigen ...... tion of a mutant p53 tetramer.
@en
A novel mechanism of tumorigen ...... tion of a mutant p53 tetramer.
@nl
type
label
A novel mechanism of tumorigen ...... tion of a mutant p53 tetramer.
@en
A novel mechanism of tumorigen ...... tion of a mutant p53 tetramer.
@nl
prefLabel
A novel mechanism of tumorigen ...... tion of a mutant p53 tetramer.
@en
A novel mechanism of tumorigen ...... tion of a mutant p53 tetramer.
@nl
P2093
P356
P1476
A novel mechanism of tumorigen ...... tion of a mutant p53 tetramer.
@en
P2093
Amanda S Lee
Brian Bothner
Craig Cadwell
Enrico L DiGiammarino
Gerard Zambetti
Raul C Ribeiro
Richard W Kriwacki
Weixing Zhang
P356
10.1038/NSB730
P577
2002-01-01T00:00:00Z