The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for ef
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Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structureMolecular mechanisms of cellular cholesterol effluxStructure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutationTryptophan 415 Is Critical for the Cholesterol Transport Functions of Scavenger Receptor BIExtracellular hydrophobic regions in scavenger receptor BI play a key role in mediating HDL-cholesterol transport.apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL.SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport.Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI.Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4Functional characterization of newly-discovered mutations in human SR-BICarboxyl terminus of apolipoprotein A-I (ApoA-I) is necessary for the transport of lipid-free ApoA-I but not prelipidated ApoA-I particles through aortic endothelial cellsNegatively cooperative binding of high-density lipoprotein to the HDL receptor SR-BIExpression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis.Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.Glycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport.Domains of apoE4 required for the biogenesis of apoE-containing HDL.Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL.Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouseAcrolein impairs the cholesterol transport functions of high density lipoproteins.High density lipoprotein structure-function and role in reverse cholesterol transport.Protein mediators of sterol transport across intestinal brush border membrane.Protein carbamylation renders high-density lipoprotein dysfunctional.Crystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoilThe carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models.Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys.Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDLSignificance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport.Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis.High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.Identification of the N-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of their effects on HDL binding and selective lipid uptake.High-density lipoprotein (HDL) metabolism and bone mass.An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI.Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux.NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper MotifPathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.Highly purified scavenger receptor class B, type I reconstituted into phosphatidylcholine/cholesterol liposomes mediates high affinity high density lipoprotein binding and selective lipid uptake.
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The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for ef
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
The effects of mutations in he ...... n and SR-BI is required for ef
@en
The effects of mutations in he ...... venger receptor class B type I
@nl
type
label
The effects of mutations in he ...... n and SR-BI is required for ef
@en
The effects of mutations in he ...... venger receptor class B type I
@nl
prefLabel
The effects of mutations in he ...... n and SR-BI is required for ef
@en
The effects of mutations in he ...... venger receptor class B type I
@nl
P2093
P2860
P356
P1476
The effects of mutations in he ...... n and SR-BI is required for ef
@en
P2093
Horng-Yuan Kan
Monty Krieger
Vassilis I Zannis
P2860
P304
21576-21584
P356
10.1074/JBC.M112103200
P407
P577
2002-03-06T00:00:00Z