Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine. - Wikidata - wikimedia - TriplyDB

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

http://www.wikidata.org/entity/Q43952477

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Pharmacogenetics of drug-metabolizing enzymes: implications for a safer and more effective drug therapy Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor The Risk of Congenital Heart Anomalies Following Prenatal Exposure to Serotonin Reuptake Inhibitors-Is Pharmacogenetics the Key?Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor PharmGKB summary: cyclosporine and tacrolimus pathways Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor.Pharmacogenetics of glucocorticoid replacement could optimize the treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.Expression and regulation of human fetal-specific CYP3A7 in mice Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes The pharmacogenetics of calcineurin inhibitors: one step closer toward individualized immunosuppression?Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms Clinical implications of CYP3A polymorphisms.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.A pharmacogenomics primer.Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.Association of genotypes of the CYP3A cluster with midazolam disposition in vivo.Pharmacogenomics of CYP3A: considerations for HIV treatment.Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine.The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy.CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy.Developmental changes in the expression and function of cytochrome P450 3A isoforms: evidence from in vitro and in vivo investigations.Cytochrome P450 pharmacogenetics in African populations.Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.Marmoset CYP3A21, a model for human CYP3A4: protein expression and functional characterization of the promoter.A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry.The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).Ontogeny of CYP3A and P-glycoprotein in the liver and the small intestine of the Göttingen minipig: an immunohistochemical evaluation.A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1.Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients.The effect of fetal androgen metabolism-related gene variants on external genitalia virilization in congenital adrenal hyperplasia.Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery.Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation.

P2860

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P2860

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

http://www.wikidata.org/entity/Q43952477

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

@en

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

@nl

type

label

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

@en

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

@nl

prefLabel

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

@en

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

@nl

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Journal of Biological Chemistry

P1476

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

@en

P2093

Andreas K Nuessler

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Elisabeth Hustert

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Hartmut Glaeser

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Heike Tegude

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Ina Koch

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Kathrin Klein

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Leszek Wojnowski

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Martin F Fromm

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Michel Eichelbaum

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Oliver Burk

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P2860

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene.

Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.

Cytochrome P-450 3A4: regulation and role in drug metabolism.

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes.

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24280-24288

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10.1074/JBC.M202345200

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27

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277

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Ulrich M. Zanger

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2002-04-08T00:00:00Z

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11425035

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11940601

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