Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.
about
Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregatesPalmitoylation of huntingtin by HIP14 is essential for its trafficking and functionOld Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative DisordersTargeting heat shock proteins to modulate α-synuclein toxicityThe choreography of neuroinflammation in Huntington's diseaseIron dysregulation in Huntington's diseaseGlobal functional analyses of cellular responses to pore-forming toxinsIntracellular cleavage of amyloid β by a viral protease NIa prevents amyloid β-mediated cytotoxicityExperimental and computational analysis of polyglutamine-mediated cytotoxicityA genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3Essential role of the NH2-terminal WD/EPF motif in the phosphorylation-activated protective function of mammalian Hsp27Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisA small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophyDysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's diseaseProbucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in ratsRole of high mobility group box 1 (HMGB1) in SCA17 pathogenesisGenome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampusAltered aggregation properties of mutant gamma-crystallins cause inherited cataractHeat shock proteins: cellular and molecular mechanisms in the central nervous system.S-glutathionylation: from molecular mechanisms to health outcomesTherapeutic prospects for spinocerebellar ataxia type 2 and 3.Behavioral defects in chaperone-deficient Alzheimer's disease model mice.An engineered viral protease exhibiting substrate specificity for a polyglutamine stretch prevents polyglutamine-induced neuronal cell death.Multiple-stress analysis for isolation of Drosophila longevity genes.Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast.Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostainingConformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative diseaseProtection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.Stress under the dam: meeting report of the Fourth International Workshop on the Molecular Biology of Stress Responses.Mutant huntingtin impairs Ku70-mediated DNA repair.Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.Ku70 alleviates neurodegeneration in Drosophila models of Huntington's diseaseDefective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.Role of the CCAAT-binding protein NFY in SCA17 pathogenesisSelective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathwaysDoxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice.
P2860
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P2860
Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Heat shock protein 27 prevents ...... species caused by huntingtin.
@en
Heat shock protein 27 prevents ...... species caused by huntingtin.
@nl
type
label
Heat shock protein 27 prevents ...... species caused by huntingtin.
@en
Heat shock protein 27 prevents ...... species caused by huntingtin.
@nl
prefLabel
Heat shock protein 27 prevents ...... species caused by huntingtin.
@en
Heat shock protein 27 prevents ...... species caused by huntingtin.
@nl
P2093
P356
P1476
Heat shock protein 27 prevents ...... species caused by huntingtin.
@en
P2093
Andre-Patrik Arrigo
Andreas Wyttenbach
Chantal Diaz-Latoud
David C Rubinsztein
Jenny Carmichael
Olivier Sauvageot
P304
P356
10.1093/HMG/11.9.1137
P577
2002-05-01T00:00:00Z