Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.
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alpha-Synuclein and neuronal cell deathThe chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicityAlpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicityParkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitroDopamine covalently modifies and functionally inactivates parkinGenetics of Parkinson diseaseDopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1Potential Role of Epigenetic Mechanism in Manganese Induced NeurotoxicityParkinson's Disease: The Mitochondria-Iron LinkNeuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathwaysThe Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α -Synuclein Levels in Parkinson's Disease: A Meta-AnalysisThe Incremental Induction of Neuroprotective Properties by Multiple Therapeutic Strategies for Primary and Secondary Neural InjuryBiophysical characterization of α-synuclein and its controversial structureThe role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelismHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation.The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseParkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation14-3-3eta is a novel regulator of parkin ubiquitin ligase.Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathiesEndonuclease G mediates α-synuclein cytotoxicity during Parkinson's diseaseOmega-3 polyunsaturated fatty acids protect neural progenitor cells against oxidative injuryDopamine and paraquat enhance α-synuclein-induced alterations in membrane conductanceInteraction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosisGenetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytesLoss of function of Ywhah in mice induces deafness and cochlear outer hair cells' degeneration.From QTL to candidate gene: a genetic approach to alcoholism researchLoss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons.At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillationTyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity.Thalamus pathology in multiple sclerosis: from biology to clinical application.Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicityElevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease.Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC regionModulation of alpha-synuclein aggregation by dopamine analogs.Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cellsOral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice
P2860
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P2860
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Dopamine-dependent neurotoxici ...... neration in Parkinson disease.
@en
Dopamine-dependent neurotoxici ...... neration in Parkinson disease.
@nl
type
label
Dopamine-dependent neurotoxici ...... neration in Parkinson disease.
@en
Dopamine-dependent neurotoxici ...... neration in Parkinson disease.
@nl
prefLabel
Dopamine-dependent neurotoxici ...... neration in Parkinson disease.
@en
Dopamine-dependent neurotoxici ...... neration in Parkinson disease.
@nl
P2093
P921
P356
P1433
P1476
Dopamine-dependent neurotoxici ...... neration in Parkinson disease.
@en
P2093
Bruce A Yankner
Frank J S Lee
Lee-Way Jin
Shyan-Yuan Kao
P2888
P304
P356
10.1038/NM0602-600
P407
P577
2002-06-01T00:00:00Z
P5875
P6179
1033109199