Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. - Wikidata - wikimedia - TriplyDB

Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.

Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.

http://www.wikidata.org/entity/Q44013452

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Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins Electrophilic affibodies forming covalent bonds to protein targets Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed Obstructing toxin pathways by targeted pore blockage Monoclonal Antibody Combinations that Present Synergistic Neutralizing Activity: A Platform for Next-Generation Anti-Toxin Drugs Antibody to ricin a chain hinders intracellular routing of toxin and protects cells even after toxin has been internalized Crystal Structure of the Engineered Neutralizing Antibody M18 Complexed to Domain 4 of the Anthrax Protective Antigen Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy Protective antigen and toxin neutralization antibody patterns in anthrax vaccinees undergoing serial plasmapheresis.Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax Efficacy of ETI-204 monoclonal antibody as an adjunct therapy in a New Zealand white rabbit partial survival model for inhalational anthrax Efficacy Projection of Obiltoxaximab for Treatment of Inhalational Anthrax across a Range of Disease Severity Rabies virus glycoprotein as a carrier for anthrax protective antigen Monoclonal antibody therapies against anthrax Rabbit and nonhuman primate models of toxin-targeting human anthrax vaccines A high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolized Bacillus anthracis spore challenge Production and characterisation of a neutralising chimeric antibody against botulinum neurotoxin A Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization.Fine Epitope Mapping of Two Antibodies Neutralizing the Bordetella Adenylate Cyclase Toxin.Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines.A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough.Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7.Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries.A general method for greatly improving the affinity of antibodies by using combinatorial libraries Selection of a macaque Fab with framework regions like those in humans, high affinity, and ability to neutralize the protective antigen (PA) of Bacillus anthracis by binding to the segment of PA between residues 686 and 694.Optimizing the affinity and specificity of proteins with molecular display.Polyvalent inhibitors of anthrax toxin that target host receptors APEx 2-hybrid, a quantitative protein-protein interaction assay for antibody discovery and engineering High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation.

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P2860

Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.

http://www.wikidata.org/entity/Q44013452

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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name

Protection against anthrax tox ...... relates with antigen affinity.

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Protection against anthrax tox ...... relates with antigen affinity.

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type

label

Protection against anthrax tox ...... relates with antigen affinity.

@en

Protection against anthrax tox ...... relates with antigen affinity.

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prefLabel

Protection against anthrax tox ...... relates with antigen affinity.

@en

Protection against anthrax tox ...... relates with antigen affinity.

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Nature Biotechnology

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Protection against anthrax tox ...... relates with antigen affinity.

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Brent L Iverson

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Catharina B M Maassen

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George Georgiou

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Jean L Patterson

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Jennifer A Maynard

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Kathleen Brasky

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597-601

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scholarly article

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10.1038/NBT0602-597

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6

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20

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Stephen H. Leppla

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2002-06-01T00:00:00Z

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11330059

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1027606865

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12042864

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