A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
about
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionThe importance of three membrane-distal tyrosines in the adaptor protein NTAL/LABThemis, a T cell-specific protein important for late thymocyte developmentDual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and toleranceEarly signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsetsGenetic deletion of Mst1 alters T cell function and protects against autoimmunityCentral tolerance: learning self-control in the thymusThe lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cellsAn intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivoHematopoietic adaptors in T-cell signaling: potential applications to transplantationQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hubFOXP3+ Tregs require WASP to restrain Th2-mediated food allergyT-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clusteringAltered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strainPhospholipase C{gamma}1 is essential for T cell development, activation, and toleranceShb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell developmentBasal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expressionMislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody productionAn architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors.Lipid signaling in T-cell development and functionThe importance of LAT in the activation, homeostasis, and regulatory function of T cellsLAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?Detection of T cell responses to a ubiquitous cellular protein in autoimmune diseaseExamining multiprotein signaling complexes from all anglesmiRNA signature of mouse helper T cell hyper-proliferationMalt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Changes in actin dynamics at the T-cell/APC interface: implications for T-cell anergy?Itk: the rheostat of the T cell response.Adaptors as central mediators of signal transduction in immune cells.Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.An evolutionary and structural perspective on T cell antigen receptor function.The role of Tec family kinases in T cell development and function.Transmembrane adapters: attractants for cytoplasmic effectors.Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development.Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
P2860
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P2860
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
@en
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
@nl
type
label
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
@en
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
@nl
prefLabel
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
@en
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
@nl
P2093
P356
P1433
P1476
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
@en
P2093
Alexander Grinberg
Cheung-Seog Park
Chiguang Feng
Claudette L Fuller
Connie L Sommers
Elizabeth W Shores
Emanuela Lacaná
Jay A Hildebrand
Lawrence E Samelson
P304
P356
10.1126/SCIENCE.1069066
P407
P577
2002-06-01T00:00:00Z