Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
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Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science studyThe protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis.Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritisThe shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.A randomized, double blind, placebo and active comparator controlled pilot study of UP446, a novel dual pathway inhibitor anti-inflammatory agent of botanical origin.Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.Activity and potential role of licofelone in the management of osteoarthritis.Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production.5-Lipoxygenase metabolic contributions to NSAID-induced organ toxicity.Persisting eicosanoid pathways in rheumatic diseases.Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety.Local inhibition of 5-lipoxygenase enhances bone formation in a rat model.Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes.Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblastsThe regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts.Current status and future prospects for disease modification in osteoarthritis.Correlation between osteoarthritic changes in the stifle joint in dogs and the results of orthopedic, radiographic, ultrasonographic and arthroscopic examinations.R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts.Human articular chondrocytes express functional leukotriene B4 receptors.
P2860
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P2860
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Study of the role of leukotriene B
@nl
Study of the role of leukotrie ...... /or 5-lipoxygenase inhibition.
@en
type
label
Study of the role of leukotriene B
@nl
Study of the role of leukotrie ...... /or 5-lipoxygenase inhibition.
@en
prefLabel
Study of the role of leukotriene B
@nl
Study of the role of leukotrie ...... /or 5-lipoxygenase inhibition.
@en
P2093
P2860
P356
P1476
Study of the role of leukotrie ...... /or 5-lipoxygenase inhibition.
@en
P2093
Daniel Lajeunesse
Frédéric Massicotte
Stefan Laufer
Yosabeth Paredes
P2860
P304
P356
10.1002/ART.10357
P577
2002-07-01T00:00:00Z