Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. - Wikidata - wikimedia - TriplyDB

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue.

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue.

http://www.wikidata.org/entity/Q44095707

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The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis Leucine is a major regulator of muscle protein synthesis in neonates Branched-chain amino acids in metabolic signalling and insulin resistance Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle Features, causes and consequences of splanchnic sequestration of amino acid in old rats A High-Protein Diet Reduces Weight Gain, Decreases Food Intake, Decreases Liver Fat Deposition, and Improves Markers of Muscle Metabolism in Obese Zucker Rats.The role of leucine and its metabolites in protein and energy metabolism.Enteral β-hydroxy-β-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs.Leucine and protein metabolism in obese Zucker rats.Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein.Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus.Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach.Triennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs.Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects.Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and the innate immune system pathway.Glutamine and leucine provide enhanced protective immunity against mucosal infection with herpes simplex virus type 1.Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs.Leucine and protein synthesis: mTOR and beyond.The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin.Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia.Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion Nutritional strategies for the preservation of fat free mass at high altitude.mTOR and the differentiation of mesenchymal stem cells.Leucine nutrition in animals and humans: mTOR signaling and beyond.Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis.Regulation of the proteome by amino acids.Inability to replete white adipose tissue during recovery phase of sepsis is associated with increased autophagy, apoptosis, and proteasome activity.Application of a nonradioactive method of measuring protein synthesis in industrially relevant Chinese hamster ovary cells.L-leucine supplementation worsens the adiposity of already obese rats by promoting a hypothalamic pattern of gene expression that favors fat accumulation.Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury.Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue.Leucine and alpha-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs.Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation.Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice.

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P2860

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue.

http://www.wikidata.org/entity/Q44095707

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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name

Leucine is a direct-acting nut ...... n synthesis in adipose tissue.

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Leucine is a direct-acting nut ...... n synthesis in adipose tissue.

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type

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Leucine is a direct-acting nut ...... n synthesis in adipose tissue.

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Leucine is a direct-acting nut ...... n synthesis in adipose tissue.

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Leucine is a direct-acting nut ...... n synthesis in adipose tissue.

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Leucine is a direct-acting nut ...... n synthesis in adipose tissue.

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AJPENDO.00084.2002

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American Journal of Physiology - Endocrinology and Metabolism

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Leucine is a direct-acting nut ...... n synthesis in adipose tissue.

@en

P2093

Alain Vaval

http://www.w3.org/2001/XMLSchema#string

Brian J Patson

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Christopher J Lynch

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Joshua Anthony

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Leonard S Jefferson

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Thomas C Vary

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P2860

TOR, a central controller of cell growth.

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

Amino acid-induced stimulation of translation initiation in rat skeletal muscle

Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2

Regulation of translation initiation by FRAP/mTOR

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway.

PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.

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scholarly article

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10.1152/AJPENDO.00084.2002

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3

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283

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51985493

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12169444

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