Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).
about
β1-adrenergic receptor antagonists signal via PDE4 translocationSelective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiationPDE4 as a target for cognition enhancementRACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in miceAttenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing.Intracellular membrane association of the Aplysia cAMP phosphodiesterase long and short forms via different targeting mechanisms.PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblastsCyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationThe upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseInactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMPEngineered stabilization and structural analysis of the autoinhibited conformation of PDE4Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsCyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signalingCritical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblastsFurther Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics.Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.Clinical and molecular genetics of the phosphodiesterases (PDEs).The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1.Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue.Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase geneMutations causing acrodysostosis-2 facilitate activation of phosphodiesterase 4D3.The GAFa domains of rod cGMP-phosphodiesterase 6 determine the selectivity of the enzyme dimerization.The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss.Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.Phosphodiesterase Diversity and Signal Processing Within cAMP Signaling Networks.Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice
P2860
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P2860
Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Dimerization of the type 4 cAM ...... ream conserved regions (UCRs).
@en
Dimerization of the type 4 cAM ...... the upstream conserved regions
@nl
type
label
Dimerization of the type 4 cAM ...... ream conserved regions (UCRs).
@en
Dimerization of the type 4 cAM ...... the upstream conserved regions
@nl
prefLabel
Dimerization of the type 4 cAM ...... ream conserved regions (UCRs).
@en
Dimerization of the type 4 cAM ...... the upstream conserved regions
@nl
P356
P1476
Dimerization of the type 4 cAM ...... ream conserved regions (UCRs).
@en
P2093
Marco Conti
P304
40212-40221
P356
10.1074/JBC.M203585200
P407
P50
P577
2002-08-12T00:00:00Z