Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
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Oxidative Stress Signaling in Alzheimers DiseaseIron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's diseaseClioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.Novel therapeutics for Alzheimer's disease: an updateMetals and amyloid-beta in Alzheimer's diseaseZinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluidWhy nutraceuticals do not prevent or treat Alzheimer's diseaseIonic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone proteinOverview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal CompoundsThe Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's DiseaseRegulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseasesStem cell treatment for Alzheimer's diseaseProtein Oxidation in Aging: Does It Play a Role in Aging Progression?Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasisIntracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification.Copper promotes the trafficking of the amyloid precursor proteinMolecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.Systemic catabolism of Alzheimer's Abeta40 and Abeta42.Mitochondrial oxidative stress causes hyperphosphorylation of tau.Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Increased expression and local accumulation of the prion protein, Alzheimer Aβ peptides, superoxide dismutase 1, and nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes.Copper(II)-human amylin complex protects pancreatic cells from amylin toxicity.The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer's Disease.The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's DiseaseAlzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination.Endogenous zinc in neurological diseases.Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's diseaseMetal and complementary molecular bioimaging in Alzheimer's disease.Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cellsMysterious oligomerization of the amyloidogenic proteinsPolymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.Metal imaging in neurodegenerative diseases.Catalytic antioxidants and neurodegenerationGenetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's diseaseEffects of a copper-deficient diet on the biochemistry, neural morphology and behavior of aged mice.
P2860
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P2860
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Metalloenzyme-like activity of ...... agents to neurotoxic H(2)O(2).
@en
Metalloenzyme-like activity of ...... agents to neurotoxic H(2)O(2).
@nl
type
label
Metalloenzyme-like activity of ...... agents to neurotoxic H(2)O(2).
@en
Metalloenzyme-like activity of ...... agents to neurotoxic H(2)O(2).
@nl
prefLabel
Metalloenzyme-like activity of ...... agents to neurotoxic H(2)O(2).
@en
Metalloenzyme-like activity of ...... agents to neurotoxic H(2)O(2).
@nl
P2093
P50
P921
P356
P1476
Metalloenzyme-like activity of ...... agents to neurotoxic H(2)O(2).
@en
P2093
Alex E Roher
Carlos Opazo
Nibaldo C Inestrosa
Robert A Cherny
Xudong Huang
P304
40302-40308
P356
10.1074/JBC.M206428200
P407
P577
2002-08-20T00:00:00Z