Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases.
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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsNonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease ChemotherapyInhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones.Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates.Identification of a new class of nonpeptidic inhibitors of cruzain.Identification and optimization of a novel inhibitor of mitochondrial calpain 10Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.Rational design of a selective covalent modifier of G protein βγ subunits.Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolaseSite-specific Labeling of a Protein Lysine Residue By Novel Kinetic Labeling Combinatorial Libraries.Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide.Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell deathRecent advances in heterolytic nucleofugal leaving groups.Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression systemUbiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery.Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases.Research strategies for design and development of NSAIDs: clue to balance potency and toxicity of acetanilide compounds.Nature of papain products resulting from inactivation by a peptidyl O-acyl hydroxamate.The aminopeptidase inhibitor, z-L-CMK, is toxic and induces cell death in Jurkat T cells through oxidative stress.Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome.ATP treatment of human monocytes promotes caspase-1 maturation and externalization.Synthesis of Polyester Dendritic Scaffolds for Biomedical Applications.Synthesis and inhibition of human leucocyte elastase by functionalized N-aryl azetidin-2-ones: effect of different substituents on the aromatic ring.The Taxonomy of Covalent InhibitorsActivation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis
P2860
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P2860
Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Peptidyl (acyloxy)methyl keton ...... ators of cysteine proteinases.
@en
type
label
Peptidyl (acyloxy)methyl keton ...... ators of cysteine proteinases.
@en
prefLabel
Peptidyl (acyloxy)methyl keton ...... ators of cysteine proteinases.
@en
P2093
P356
P1433
P1476
Peptidyl (acyloxy)methyl keton ...... ators of cysteine proteinases.
@en
P2093
P304
P356
10.1021/BI00233A007
P407
P577
1991-05-01T00:00:00Z