Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
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The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationRegulation of Fyn through translocation of activated Lck into lipid raftsRegulation of FynT function by dual domain docking on PAG/CbpLyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cellsOccurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytesPhosphorylation site dynamics of early T-cell receptor signalingInteractions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity.C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain.The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton.Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strengthT cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and functionUnaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice.The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability.Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts.Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cellsDifferential subcellular distribution of rat brain dopamine receptors and subtype-specific redistribution induced by cocaine.SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signalingTransmembrane adapters: attractants for cytoplasmic effectors.Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase αPAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.Transmembrane adaptor proteins: organizers of immunoreceptor signalling.Molecular interdiction of Src-family kinase signaling in hematopoietic cells.Regulation of T-cell receptor signalling by membrane microdomains.Lipid rafts in T cell receptor signallingLipid rafts in T cell signalling and disease.Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization.Lipid rafts and T-lymphocyte function: implications for autoimmunity.Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling.Intracellular cholesterol homeostasis and amyloid precursor protein processing.Plasma membrane microdomains in aging and disease.The role of membrane rafts in Lck transport, regulation and signalling in T-cells.PAG--a multipurpose transmembrane adaptor protein.Aging, immunosenescence and membrane rafts: the lipid connectionA new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.
P2860
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P2860
Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Cutting edge: Fyn is essential ...... ipid rafts in resting T cells.
@en
Cutting edge: Fyn is essential ...... ipid rafts in resting T cells.
@nl
type
label
Cutting edge: Fyn is essential ...... ipid rafts in resting T cells.
@en
Cutting edge: Fyn is essential ...... ipid rafts in resting T cells.
@nl
prefLabel
Cutting edge: Fyn is essential ...... ipid rafts in resting T cells.
@en
Cutting edge: Fyn is essential ...... ipid rafts in resting T cells.
@nl
P2093
P1476
Cutting edge: Fyn is essential ...... lipid rafts in resting T cells
@en
P2093
Akiko Kato
Atsushi Kosugi
Masakazu Nagafuku
Masato Okada
Takaki Shima
Takenao Yamada
Takeshi Yagi
Toshiyuki Hamaoka
Yasuko Minaki
P304
P356
10.4049/JIMMUNOL.169.6.2813
P407
P577
2002-09-01T00:00:00Z