Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.
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Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells.T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli.Constitutively active Lck kinase in T cells drives antigen receptor signal transductionThe role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.Membrane domains in lymphocytes - from lipid rafts to protein scaffolds.Regulation of T-cell receptor signalling by membrane microdomains.Lipid rafts in T cell receptor signallingDo membrane rafts contribute to human immunosenescence?Lipid rafts in T cell signalling and disease.Lipid rafts and T-lymphocyte function: implications for autoimmunity.Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus.CD4 and CD8: an inside-out coreceptor model for innate immune cells.The role of membrane rafts in Lck transport, regulation and signalling in T-cells.Regulation of expression and function of Lck tyrosine kinase by high cell density.A negatively charged domain of LAT mediates its interaction with the active form of Lck.LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic.Plasma membrane subdomain partitioning of Lck in primary human T lymphocytes.CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor.A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling.The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion.
P2860
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P2860
Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.
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2003 nî lūn-bûn
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Selective interaction of LAT ( ...... regulation of Lck in T cells.
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type
label
Selective interaction of LAT ( ...... regulation of Lck in T cells.
@en
prefLabel
Selective interaction of LAT ( ...... regulation of Lck in T cells.
@en
P2860
P356
P1433
P1476
Selective interaction of LAT ( ...... regulation of Lck in T cells.
@en
P2093
Panagiotis S Kabouridis
P2860
P304
P356
10.1042/BJ20021578
P407
P577
2003-05-01T00:00:00Z