Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
about
Evidence for natural antisense transcript-mediated inhibition of microRNA functionAlpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brainLRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseAmyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsExpression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretaseSignaling effect of amyloid-beta(42) on the processing of AbetaPPSynaptic Cell Adhesion Molecules in Alzheimer's DiseasePlatelets and Alzheimer's disease: Potential of APP as a biomarkerUshering in the study and treatment of preclinical Alzheimer diseaseDifferential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's diseaseDiscovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Diseaseβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseBACE1 expression and activity: relevance in Alzheimer's diseaseMolecular mechanisms of cognitive dysfunction following traumatic brain injuryBACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous systemMutation of active site residues of insulin-degrading enzyme alters allosteric interactionsDepletion of GGA1 and GGA3 mediates postinjury elevation of BACE1Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's diseaseNumerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic SynapsesBridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive PotentialPhosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation.BACE1 and BACE2 enzymatic activities in Alzheimer's disease.Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy.Pharmacology of epigenetics in brain disordersPhospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD miceThe expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.Viable mouse gene ablations that robustly alter brain Aβ levels are rare.Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic miceFunctional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex.Recent insights into the molecular genetics of dementiaGenetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque developmentGenetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brainsKnock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes
P2860
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P2860
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
@en
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
@nl
type
label
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
@en
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
@nl
prefLabel
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
@en
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
@nl
P2093
P1433
P1476
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
@en
P2093
Bonnie S Cheung
Hiroaki Fukumoto
Michael C Irizarry
P304
P356
10.1001/ARCHNEUR.59.9.1381
P577
2002-09-01T00:00:00Z