Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria.
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Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in miceWorms, bacteria, and micronutrients: an elegant model of our dietGenetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase.The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis.Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effectsSex differences in carbohydrate metabolism are linked to gene expression in Caenorhabditis elegansAarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal AccumulationSEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activityPrimary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal diseaseThe matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegansPathomechanisms in coenzyme q10-deficient human fibroblasts.Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesisLipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria.Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q.Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.Endogenous ROS levels in C. elegans under exogenous stress support revision of oxidative stress theory of life-history tradeoffsCaenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport.Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation.Compatibility between mitochondrial and nuclear genomes correlates with the quantitative trait of lifespan in Caenorhabditis elegans.Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans.Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants.Coenzyme Q and mitochondrial diseaseMolecular genetics of ubiquinone biosynthesis in animals.Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction.Dietary and microbiome factors determine longevity in Caenorhabditis elegans.Mitochondrial respiration without ubiquinone biosynthesis.Fluorescence-based fixative and vital staining of lipid droplets in Caenorhabditis elegans reveal fat stores using microscopy and flow cytometry approaches.Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondriaThe role of DMQ(9) in the long-lived mutant clk-1.The effect of different ubiquinones on lifespan in Caenorhabditis elegans.Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development.Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length.Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.Cell Biology of the Mitochondrion.Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.
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Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Development and fertility in C ...... y coenzyme Q8 to mitochondria.
@en
Development and fertility in C ...... y coenzyme Q8 to mitochondria.
@nl
type
label
Development and fertility in C ...... y coenzyme Q8 to mitochondria.
@en
Development and fertility in C ...... y coenzyme Q8 to mitochondria.
@nl
prefLabel
Development and fertility in C ...... y coenzyme Q8 to mitochondria.
@en
Development and fertility in C ...... y coenzyme Q8 to mitochondria.
@nl
P2093
P2860
P356
P1476
Development and fertility in C ...... y coenzyme Q8 to mitochondria.
@en
P2093
Beth N Marbois
Catherine F Clarke
Kym F Faull
Pamela L Larsen
Tanya Jonassen
P2860
P304
45020-45027
P356
10.1074/JBC.M204758200
P407
P577
2002-09-24T00:00:00Z