about
Weak selection and protein evolutionExperimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolutionThe role of robustness in phenotypic adaptation and innovationPervasive cryptic epistasis in molecular evolutionDifferential Strengths of Positive Selection Revealed by Hitchhiking Effects at Small Physical Scales in Drosophila melanogasterHuman allelic variation: perspective from protein function, structure, and evolution.Estimating the rate of irreversibility in protein evolution.Mutations of the Drosophila zinc finger-encoding gene vielfältig impair mitotic cell divisions and cause improper chromosome segregation.Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.From bad to good: Fitness reversals and the ascent of deleterious mutationsUnderstanding the evolutionary fate of finite populations: the dynamics of mutational effects.Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components.The use of orthologous sequences to predict the impact of amino acid substitutions on protein function.Why human disease-associated residues appear as the wild-type in other species: genome-scale structural evidence for the compensation hypothesis.Causes of molecular convergence and parallelism in protein evolution.Correlated evolution of nearby residues in Drosophilid proteinsEpistasis between beneficial mutations and the phenotype-to-fitness Map for a ssDNA virus.Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae.Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations.Parallel genome-wide fixation of ancestral alleles in partially outcrossing experimental populations of Caenorhabditis elegans.Missense meanderings in sequence space: a biophysical view of protein evolution.Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of DrosophilaEffects of host plant and genetic background on the fitness costs of resistance to Bacillus thuringiensis.Genetic constraints on protein evolutionEvolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map.Two types of cis-trans compensation in the evolution of transcriptional regulationEvolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome.An empirical test of the concomitantly variable codon hypothesis.Identification of cis-suppression of human disease mutations by comparative genomics.Amino acid coevolution induces an evolutionary Stokes shift.Mutation Rate Variation is a Primary Determinant of the Distribution of Allele Frequencies in Humans.Changing preferences: deformation of single position amino acid fitness landscapes and evolution of proteinsProtein co-evolution, co-adaptation and interactions.Co-evolution and co-adaptation in protein networks.Capturing the mutational landscape of the beta-lactamase TEM-1.Molecular population genetics and selection in the glycolytic pathway.Compensated pathogenic deviations.Epistasis in protein evolution.Mechanisms of suppression: The wiring of genetic resilience.Tools for Predicting the Functional Impact of Nonsynonymous Genetic Variation.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Compensated deleterious mutations in insect genomes.
@en
Compensated deleterious mutations in insect genomes.
@nl
type
label
Compensated deleterious mutations in insect genomes.
@en
Compensated deleterious mutations in insect genomes.
@nl
prefLabel
Compensated deleterious mutations in insect genomes.
@en
Compensated deleterious mutations in insect genomes.
@nl
P2093
P356
P1433
P1476
Compensated deleterious mutations in insect genomes.
@en
P2093
Brian R Bettencourt
Daniel L Hartl
Rob J Kulathinal
P304
P356
10.1126/SCIENCE.1100522
P407
P577
2004-10-21T00:00:00Z