Capturing the mutational landscape of the beta-lactamase TEM-1. - Wikidata - wikimedia - TriplyDB

Capturing the mutational landscape of the beta-lactamase TEM-1.

Capturing the mutational landscape of the beta-lactamase TEM-1.

http://www.wikidata.org/entity/Q37088726

about

Escherichia coli β-Lactamases: What Really Matters High-Throughput Screening in Protein Engineering: Recent Advances and Future Perspectives Contingency and entrenchment in protein evolution under purifying selection Characterization of all possible single-nucleotide change caused amino acid substitutions in the kinase domain of Bruton tyrosine kinase.Benchmarking Inverse Statistical Approaches for Protein Structure and Design with Exactly Solvable Models.Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server The Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.Effects of new mutations on fitness: insights from models and data.Improving landscape inference by integrating heterogeneous data in the inverse Ising problem.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.A comprehensive, high-resolution map of a gene's fitness landscape Emergence and spread of antibiotic resistance: setting a parameter space.Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Inferring fitness landscapes by regression produces biased estimates of epistasis.Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.A systematic survey of an intragenic epistatic landscape.Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina Molecular evolution accompanying functional divergence of duplicated genes along the plant starch biosynthesis pathway How structural and physicochemical determinants shape sequence constraints in a functional enzyme Thermal stabilization of dihydrofolate reductase using monte carlo unfolding simulations and its functional consequences.Dissecting enzyme function with microfluidic-based deep mutational scanning Quantitative Description of a Protein Fitness Landscape Based on Molecular Features.Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders.Biophysical principles predict fitness landscapes of drug resistance.Local fitness landscape of the green fluorescent protein.Adaptation in protein fitness landscapes is facilitated by indirect paths Genetic variation in adaptability and pleiotropy in budding yeast.The Utility of Fisher's Geometric Model in Evolutionary Genetics.Epistasis in protein evolution.Mutation effects predicted from sequence co-variation.A Quantitative Model to Estimate Drug Resistance in Pathogens.Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis.On the Causes of Evolutionary Transition:Transversion Bias.A Statistical Guide to the Design of Deep Mutational Scanning Experiments.Network Analysis of Sequence-Function Relationships and Exploration of Sequence Space of TEM β-Lactamases.Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites.The fitness landscape of a tRNA gene.Inference of Distribution of Fitness Effects and Proportion of Adaptive Substitutions from Polymorphism Data.

P2860

Q26749590-64209D6A-4D2C-4E54-AF21-C134D2410895 Q26780446-A86A1870-733F-47D2-9C29-3FB33E714660 Q28647800-7A039CFB-CACC-47D7-A240-C05FCAC20ADD Q30372772-44C0A2A4-571B-4C02-9C07-7D00ECC60319 Q30388077-6E2051D5-7759-4F24-854A-084B1C7F28B4 Q30389475-BAEBBC1F-BEFD-4BA5-AA47-3AD87D795E9C Q30401012-677BD6CC-A29B-4D22-87BD-70405B36D3C2 Q30828514-A1992F2F-91D1-43E8-AF6A-BDFA237D7408 Q31144691-4B6606A1-2E73-4CED-91B9-7863B6E88FD5 Q33590790-9A8FB7F1-0BAE-4700-8BA3-999F2A2AA855 Q33642802-1E3868D5-959B-4327-8FF8-C9032F0FF6B3 Q33654337-225D22D1-D2D2-450C-BF68-164930F4CFA6 Q33667581-D1841797-6433-4BAE-A367-0964CD229DD0 Q33692707-A7975994-8472-4E0F-91B5-754DA242DFF8 Q33730568-B9DAC09F-671E-4228-BD78-07ABD86E4B9E Q33786307-57E6D842-B7EC-4877-8A4B-A5FDA77C42D6 Q34497324-9B4F5B8F-C8A0-448C-B996-9ABB6BBE588A Q34740848-BD65A084-6596-45D3-969E-544F12A3877C Q34923275-DE3FD538-34EF-4479-842F-2C25E6223DE9 Q35177647-DA977BED-2DD4-4910-8EB9-C3EA8D547CE1 Q35565904-AF47C060-B9B2-483E-9248-F7A92B6DB90A Q35612683-A3DF92B7-F79C-46C9-BCDE-1BFC9954BBFA Q35740372-123A3C4A-C9A9-43A7-BBF2-CF6AD57EEFB9 Q35765112-89DBF682-530E-431C-83E6-30C1DFC125CA Q36221173-172385B8-5646-4915-A04E-E4EE43722B85 Q36710493-A6346A6D-1B4F-4728-B10C-66EB84633695 Q37142510-8A086500-87B1-4FCC-AF3D-59263FA8B25E Q37175865-8F805351-9D31-42AB-B0C6-A23C8584C761 Q38639465-819F2829-0D2D-4277-A2EE-F96C1A13C011 Q38689208-0544B286-91FB-420D-8ED7-5231BE900FC9 Q38718935-6CE0341F-511B-44D5-9A1B-1A0A97A391CB Q39018179-91476A2F-5A77-46D4-8B64-908CDF505B04 Q39064618-2FB631F4-7489-4844-A32E-0957D59F8628 Q39226164-5E7BA34C-4ACD-4200-BEDC-505A7E16D067 Q40272968-FF9206AE-9A9C-4DA0-A52E-2EA5DC315BA2 Q41021919-8568FADE-6EBC-441B-937F-A3B065806D02 Q41290461-807E2F63-70C7-42D6-8942-3047D7F4D7A8 Q41342939-7D702367-22F7-487D-B3D6-72B7476275D5 Q41787386-76FA3CE8-C26B-4290-BED0-9DF630A562BD Q42693407-3226161B-18AD-48C6-BCEB-38C511A55754

P2860

Capturing the mutational landscape of the beta-lactamase TEM-1.

http://www.wikidata.org/entity/Q37088726

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 22 July 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Capturing the mutational landscape of the beta-lactamase TEM-1.

@en

Capturing the mutational landscape of the beta-lactamase TEM-1.

@nl

type

label

Capturing the mutational landscape of the beta-lactamase TEM-1.

@en

Capturing the mutational landscape of the beta-lactamase TEM-1.

@nl

prefLabel

Capturing the mutational landscape of the beta-lactamase TEM-1.

@en

Capturing the mutational landscape of the beta-lactamase TEM-1.

@nl

P1433

Q37088726-75ABF7FF-2CF9-4323-BB1E-B5A4F4441FA5

P1476

Q37088726-DE89205F-06DE-4425-BE87-E0D82019DCD9

P2093

Q37088726-3A280581-BAA6-4EC4-B649-D6C958917D48

Q37088726-8081FCD8-5A51-4307-A9E0-C0E0891B9990

Q37088726-9599E41D-A70D-4F79-AC70-8F8AFEAA0892

Q37088726-9A2CD9BB-5E28-4B05-9A6F-ADBCCFAEA1A6

Q37088726-B0FEADD1-EAEB-45EB-BA7A-94EE11E8803D

Q37088726-C7AE4E7D-55FE-4742-87A2-6903D597E0BF

Q37088726-D0396316-7660-4E07-BBA0-DC1B8B1F471E

Q37088726-EBEC7FDA-BE55-4800-A6D3-5AEFDDE4BAB8

P2860

Q37088726-01B7EF5C-74FA-4937-A222-35746E56319E

Q37088726-05A1F61E-9232-4A74-BC4E-F7623B01C651

Q37088726-1200F6E4-B3F8-4123-B626-D0B5DBDBFFC0

Q37088726-12EDD632-EB97-4827-82D1-B6B62D264B1C

Q37088726-27D2A28E-0E8F-4EDC-A76F-D2B8C294BCC9

Q37088726-2BBB9A2A-4AD8-4633-A9BB-39EF89CB98DD

Q37088726-368E2895-FD76-474C-A5C9-89177B380509

Q37088726-37E45080-ECDA-44EA-9717-BB037BACCEB5

Q37088726-3AFCB3FD-9B40-43F7-B1CA-42819CAC47CA

Q37088726-4371D700-DFD1-4808-850E-47185963EF09

P304

Q37088726-0E4FC72B-1BB2-4A44-B947-9785C8A12826

P31

Q37088726-AE5875B4-6582-4305-A6A5-2DED7D73CC28

P356

Q37088726-DF65A065-C104-4584-958A-34C6FD90A6D3

P407

Q37088726-9C6A40F5-9726-4288-8E3D-F18938E63193

P433

Q37088726-34ED664C-FADC-4E5C-8FCE-AE3F9F453F14

P478

Q37088726-5F01FB7B-7B59-4850-BAB7-CE011C661392

P50

Q37088726-14830C5B-9DC5-4765-922D-2F995D41F3DB

Q37088726-4CB213EB-829A-409C-A1A1-A9EDD1C6B113

Q37088726-94E93C9E-0F07-449B-932F-BEF74C79EC6A

Q37088726-97DB6752-C5E5-4241-99A7-8E85BAF649DC

P577

Q37088726-FE216188-23C8-4975-9BD8-5CCB880BB9B6

P5875

Q37088726-AF0BE92D-3BC7-4D10-8387-B756AF8F4AB6

P698

Q37088726-E6CD3A0E-3F47-4DD4-908C-FD6C506CE82E

P932

Q37088726-83E52FD0-F330-49F0-BEB7-D2D78ABDC5FC

P356

PNAS.1215206110

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Capturing the mutational landscape of the beta-lactamase TEM-1.

@en

P2093

André Birgy

http://www.w3.org/2001/XMLSchema#string

Emmanuelle Petit

http://www.w3.org/2001/XMLSchema#string

Emmanuelle Schmitt

http://www.w3.org/2001/XMLSchema#string

Guilène Barnaud

http://www.w3.org/2001/XMLSchema#string

Hervé Jacquier

http://www.w3.org/2001/XMLSchema#string

Hervé Le Nagard

http://www.w3.org/2001/XMLSchema#string

Jérémy Glodt

http://www.w3.org/2001/XMLSchema#string

Pierre-Alexis Gros

http://www.w3.org/2001/XMLSchema#string

P2860

The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus

The distribution of fitness effects of new mutations

An integrated view of protein evolution

The FoldX web server: an online force field

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat

Thermodynamic prediction of protein neutrality

Amino acid substitution matrices from protein blocks

The interface of protein structure, protein biophysics, and molecular evolution

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

P304

13067-13072

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1215206110

http://www.w3.org/2001/XMLSchema#string

P407

P433

32

http://www.w3.org/2001/XMLSchema#string

P478

110

http://www.w3.org/2001/XMLSchema#string

P50

Beatrice Bercot

Olivier Tenaillon

P577

2013-07-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

251235299

http://www.w3.org/2001/XMLSchema#string

P698

23878237

http://www.w3.org/2001/XMLSchema#string

P932

3740883

http://www.w3.org/2001/XMLSchema#string