Capturing the mutational landscape of the beta-lactamase TEM-1.
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Escherichia coli β-Lactamases: What Really MattersHigh-Throughput Screening in Protein Engineering: Recent Advances and Future PerspectivesContingency and entrenchment in protein evolution under purifying selectionCharacterization of all possible single-nucleotide change caused amino acid substitutions in the kinase domain of Bruton tyrosine kinase.Benchmarking Inverse Statistical Approaches for Protein Structure and Design with Exactly Solvable Models.Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated serverThe Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.Effects of new mutations on fitness: insights from models and data.Improving landscape inference by integrating heterogeneous data in the inverse Ising problem.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.A comprehensive, high-resolution map of a gene's fitness landscapeEmergence and spread of antibiotic resistance: setting a parameter space.Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Inferring fitness landscapes by regression produces biased estimates of epistasis.Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encodedCoevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.A systematic survey of an intragenic epistatic landscape.Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in ArgentinaMolecular evolution accompanying functional divergence of duplicated genes along the plant starch biosynthesis pathwayHow structural and physicochemical determinants shape sequence constraints in a functional enzymeThermal stabilization of dihydrofolate reductase using monte carlo unfolding simulations and its functional consequences.Dissecting enzyme function with microfluidic-based deep mutational scanningQuantitative Description of a Protein Fitness Landscape Based on Molecular Features.Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders.Biophysical principles predict fitness landscapes of drug resistance.Local fitness landscape of the green fluorescent protein.Adaptation in protein fitness landscapes is facilitated by indirect pathsGenetic variation in adaptability and pleiotropy in budding yeast.The Utility of Fisher's Geometric Model in Evolutionary Genetics.Epistasis in protein evolution.Mutation effects predicted from sequence co-variation.A Quantitative Model to Estimate Drug Resistance in Pathogens.Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis.On the Causes of Evolutionary Transition:Transversion Bias.A Statistical Guide to the Design of Deep Mutational Scanning Experiments.Network Analysis of Sequence-Function Relationships and Exploration of Sequence Space of TEM β-Lactamases.Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites.The fitness landscape of a tRNA gene.Inference of Distribution of Fitness Effects and Proportion of Adaptive Substitutions from Polymorphism Data.
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Capturing the mutational landscape of the beta-lactamase TEM-1.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 22 July 2013
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Capturing the mutational landscape of the beta-lactamase TEM-1.
@en
Capturing the mutational landscape of the beta-lactamase TEM-1.
@nl
type
label
Capturing the mutational landscape of the beta-lactamase TEM-1.
@en
Capturing the mutational landscape of the beta-lactamase TEM-1.
@nl
prefLabel
Capturing the mutational landscape of the beta-lactamase TEM-1.
@en
Capturing the mutational landscape of the beta-lactamase TEM-1.
@nl
P2093
P2860
P50
P356
P1476
Capturing the mutational landscape of the beta-lactamase TEM-1.
@en
P2093
André Birgy
Emmanuelle Petit
Emmanuelle Schmitt
Guilène Barnaud
Hervé Jacquier
Hervé Le Nagard
Jérémy Glodt
Pierre-Alexis Gros
P2860
P304
13067-13072
P356
10.1073/PNAS.1215206110
P407
P577
2013-07-22T00:00:00Z