Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.
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The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrilsHuman apolipoprotein A-I-derived amyloid: its association with atherosclerosisThe crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment.Proteomics in protein misfolding diseases.Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I.Amyloid formation from an α-helix peptide bundle is seeded by 3(10)-helix aggregates.Conformational preferences of a 14-residue fibrillogenic peptide from acetylcholinesteraseNBD-labeled phospholipid accelerates apolipoprotein C-II amyloid fibril formation but is not incorporated into mature fibrils.Small amphipathic molecules modulate secondary structure and amyloid fibril-forming kinetics of Alzheimer disease peptide Aβ(1-42).Novel N-terminal mutation of human apolipoprotein A-I reduces self-association and impairs LCAT activationSerine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid depositsEPR assessment of protein sites for incorporation of Gd(III) MRI contrast labelsSecondary structure changes in ApoA-I Milano (R173C) are not accompanied by a decrease in protein stability or solubility.Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I.Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes.Molecular interactions in the formation and deposition of beta2-microglobulin-related amyloid fibrils.Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation.Structure, function and amyloidogenic propensity of apolipoprotein A-I.A common beta-sheet architecture underlies in vitro and in vivo beta2-microglobulin amyloid fibrilsMapping the structural transition in an amyloidogenic apolipoprotein A-IApolipoproteins and amyloid fibril formation in atherosclerosis.Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation.Apolipoprotein A-I: the dual face of a protein.The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils.Apolipoprotein A-I coating of protamine-oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood-brain barrierInsights into the fate of the N-terminal amyloidogenic polypeptide of ApoA-I in cultured target cellsAmyloid fibril formation can proceed from different conformations of a partially unfolded protein.Hepatic amyloidosis resulting from deposition of the apolipoprotein A-I variant Leu75Pro.Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solution.Two different types of amyloid deposits--apolipoprotein A-IV and transthyretin--in a patient with systemic amyloidosis.Heparin promotes fibril formation by the N-terminal fragment of amyloidogenic apolipoprotein A-I.Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I.
P2860
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P2860
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.
description
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name
Conformational switching and f ...... ragment of apolipoprotein a-I.
@en
Conformational switching and f ...... ragment of apolipoprotein a-I.
@nl
type
label
Conformational switching and f ...... ragment of apolipoprotein a-I.
@en
Conformational switching and f ...... ragment of apolipoprotein a-I.
@nl
prefLabel
Conformational switching and f ...... ragment of apolipoprotein a-I.
@en
Conformational switching and f ...... ragment of apolipoprotein a-I.
@nl
P2093
P2860
P50
P356
P1476
Conformational switching and f ...... fragment of apolipoprotein a-I
@en
P2093
Alessia Andreola
Enrico Monzani
Monica Stoppini
Palma Mangione
Sofia Giorgetti
P2860
P304
P356
10.1074/JBC.M204801200
P407
P577
2002-11-05T00:00:00Z